Novel Mechanisms of Compromised Lymphatic Endothelial Cell Homeostasis in Obesity: The Role of Leptin in Lymphatic Endothelial Cell Tube Formation and Proliferation

Akinori Sato; Ryuta Kamekura; Koji Kawata; Masaya Kawada; Sumito Jitsukawa; Keiji Yamashita; Noriyuki Sato; Tetsuo Himi; Shingo Ichimiya

doi:10.1371/journal.pone.0158408

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Open Access

Peer-reviewed

Research Article

Novel Mechanisms of Compromised Lymphatic Endothelial Cell Homeostasis in Obesity: The Role of Leptin in Lymphatic Endothelial Cell Tube Formation and Proliferation

Akinori Sato ,

Contributed equally to this work with: Akinori Sato, Ryuta Kamekura

Affiliations Department of Human Immunology, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan, Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan, Division of Breast Surgery, KKR Sapporo Medical Center Tonan Hospital, Sapporo, Japan
⨯
Ryuta Kamekura ,

Contributed equally to this work with: Akinori Sato, Ryuta Kamekura

Affiliations Department of Human Immunology, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan, Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
⨯
Koji Kawata,

Affiliation Department of Human Immunology, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
⨯
Masaya Kawada,

Affiliation Division of Breast Surgery, KKR Sapporo Medical Center Tonan Hospital, Sapporo, Japan
⨯
Sumito Jitsukawa,

Affiliations Department of Human Immunology, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan, Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
⨯
Keiji Yamashita,

Affiliations Department of Human Immunology, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan, Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
⨯
Noriyuki Sato,

Affiliation Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
⨯
Tetsuo Himi,

Affiliation Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
⨯
Shingo Ichimiya

* E-mail: ichimiya@sapmed.ac.jp

Affiliation Department of Human Immunology, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
⨯

Novel Mechanisms of Compromised Lymphatic Endothelial Cell Homeostasis in Obesity: The Role of Leptin in Lymphatic Endothelial Cell Tube Formation and Proliferation

Akinori Sato,
Ryuta Kamekura,
Koji Kawata,
Masaya Kawada,
Sumito Jitsukawa,
Keiji Yamashita,
Noriyuki Sato,
Tetsuo Himi,
Shingo Ichimiya

Published: July 1, 2016
https://doi.org/10.1371/journal.pone.0158408

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Endothelial cells
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Cell proliferation
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STAT signaling
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Antibody therapy
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