Conjugation of Methotrexate-Amino Derivatives to Macromolecules through Carboxylate Moieties Is Superior Over Conventional Linkage to Amino Residues: Chemical, Cell-Free and In Vitro Characterizations

Open Access

Peer-reviewed

Research Article

Itzik Cooper ,

* E-mail: Itzik.cooper@sheba.health.gov.il

Affiliation BBB-group, The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621, Israel
⨯
Mati Fridkin,

Affiliation Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, 76100, Israel
⨯
Yoram Shechter

Affiliation Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, 76100, Israel
⨯

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Hydrolysis
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Glutamic acid
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Ethylene
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Methotrexate
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Glioma cells
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Macromolecules
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