Pegylated Interferon α-2a Triggers NK-Cell Functionality and Specific T-Cell Responses in Patients with Chronic HBV Infection without HBsAg Seroconversion

• Juliana Bruder Costa,

  Affiliations University Grenoble Alpes, Grenoble, F-38041 France; INSERM, U1209, Immunobiology and Immunotherapy of Chronic Deseases, La Tronche, F-38706 France, CHU Grenoble, Michallon Hospital, Hepato-gastroenterology unit, Grenoble, F-38043 France

  ⨯
• Tania Dufeu-Duchesne,

  Affiliations CHU Grenoble, Michallon Hospital, Hepato-gastroenterology unit, Grenoble, F-38043 France, University Grenoble Alpes, Grenoble, F-38041 France; INSERM, U1209, Analytic Immunology of chronic pathologies, La Tronche, F-38706 France

  ⨯
• Vincent Leroy,

  Affiliations CHU Grenoble, Michallon Hospital, Hepato-gastroenterology unit, Grenoble, F-38043 France, University Grenoble Alpes, Grenoble, F-38041 France; INSERM, U1209, Analytic Immunology of chronic pathologies, La Tronche, F-38706 France

  ⨯
• Inga Bertucci,

  Affiliation ANRS (France REcherche Nord & sud Sida-hiv Hépatites: FRENSH), Paris, France

  ⨯
• Magali Bouvier-Alias,

  Affiliation Department of Virology, Henri Mondor Hospital, University Paris-Est and Inserm U955, Creteil, France

  ⨯
• Noelle Pouget,

  Affiliation Sorbonne Universités, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d’épidémiologie et de Santé Publique (IPLESP UMRS 1136), 75012, Paris, France

  ⨯
• Ophelie Brevot-Lutton,

  Affiliation Sorbonne Universités, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d’épidémiologie et de Santé Publique (IPLESP UMRS 1136), 75012, Paris, France

  ⨯
• Marc Bourliere,

  Affiliation Hepato-gastroenterology department Hospital Saint Joseph, Marseille, 13008 France

  ⨯
• Fabien Zoulim,

  Affiliations INSERM U1052—CNRS 5286, Cancer Research Center of Lyon (CRCL), Lyon, France, Hepatology Department, Hospices Civils de Lyon, Lyon, France, Université de Lyon, Lyon, France

  ⨯
• Joel Plumas ,

  Contributed equally to this work with: Joel Plumas, Caroline Aspord

  * E-mail: carolineaspord@yahoo.com (CA); joel.plumas@efs.sante.fr (JP)

  Affiliations University Grenoble Alpes, Grenoble, F-38041 France; INSERM, U1209, Immunobiology and Immunotherapy of Chronic Deseases, La Tronche, F-38706 France, EFS Rhone-Alpes, R&D Laboratory, La Tronche, F-38701 France

  ⨯
• Caroline Aspord ,

  Contributed equally to this work with: Joel Plumas, Caroline Aspord

  * E-mail: carolineaspord@yahoo.com (CA); joel.plumas@efs.sante.fr (JP)

  Affiliations University Grenoble Alpes, Grenoble, F-38041 France; INSERM, U1209, Immunobiology and Immunotherapy of Chronic Deseases, La Tronche, F-38706 France, EFS Rhone-Alpes, R&D Laboratory, La Tronche, F-38701 France

  ⨯
• ANRS HB06 PEGAN study group

  ¶Membership of the ANRS HB06 PEGAN study group is listed in the Acknowledgments.

  ⨯