Internal Tandem Duplication in FLT3 Attenuates Proliferation and Regulates Resistance to the FLT3 Inhibitor AC220 by Modulating p21^Cdkn1a and Pbx1 in Hematopoietic Cells

• Mariko Abe ,

  * E-mail: itomari@med.shimane-u.ac.jp (MA); sfukuda@med.shimane-u.ac.jp (SF)

  Affiliation Department of Pediatrics, Shimane University School of Medicine, Izumo, Shimane, Japan

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• Louis M. Pelus,

  Affiliation Department of Microbiology/Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

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• Pratibha Singh,

  Affiliation Department of Microbiology/Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

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• Tomohiro Hirade,

  Affiliation Department of Pediatrics, Shimane University School of Medicine, Izumo, Shimane, Japan

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• Chie Onishi,

  Affiliation Department of Oncology/Hematology, Shimane University School of Medicine, Izumo, Shimane, Japan

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• Jamiyan Purevsuren,

  Affiliation Department of Pediatrics, Shimane University School of Medicine, Izumo, Shimane, Japan

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• Takeshi Taketani,

  Affiliations Department of Pediatrics, Shimane University School of Medicine, Izumo, Shimane, Japan, Division of Blood Transfusion, Shimane University Hospital, Izumo, Shimane, Japan

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• Seiji Yamaguchi,

  Affiliation Department of Pediatrics, Shimane University School of Medicine, Izumo, Shimane, Japan

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• Seiji Fukuda

  * E-mail: itomari@med.shimane-u.ac.jp (MA); sfukuda@med.shimane-u.ac.jp (SF)

  Affiliation Department of Pediatrics, Shimane University School of Medicine, Izumo, Shimane, Japan

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