Neprilysin Inhibits Coagulation through Proteolytic Inactivation of Fibrinogen

Open Access

Peer-reviewed

Research Article

Matthew Burrell,

Affiliation Antibody Discovery and Protein Engineering, MedImmune, Milstein Building, Granta Park, Cambridge, United Kingdom
⨯
Simon J. Henderson,

Affiliation Biologics Safety Assessment, MedImmune, Aaron Klug Building, Granta Park, Cambridge, United Kingdom
⨯
Anna Ravnefjord,

Affiliation Cardiovascular and Metabolic Disease iMed, AstraZeneca R&D, SE-431 83 Mölndal, Sweden
⨯
Fritz Schweikart,

Affiliation Pharmaceutical Development, AstraZeneca R&D, SE-431 83 Mölndal, Sweden
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Susan B. Fowler,

Affiliation Antibody Discovery and Protein Engineering, MedImmune, Milstein Building, Granta Park, Cambridge, United Kingdom
⨯
Susanne Witt,

Affiliation Antibody Discovery and Protein Engineering, MedImmune, Milstein Building, Granta Park, Cambridge, United Kingdom
⨯
Kenny M. Hansson,

Affiliation Cardiovascular and Metabolic Disease iMed, AstraZeneca R&D, SE-431 83 Mölndal, Sweden
⨯
Carl I. Webster

* E-mail: websterc@medimmune.com

Affiliation Antibody Discovery and Protein Engineering, MedImmune, Milstein Building, Granta Park, Cambridge, United Kingdom
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Fibrinogen
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Blood plasma
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Fibrin
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Monkeys
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Thrombin
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Plasma proteins
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Plasmins
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Serine proteases
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