Reactivation of Endogenous Genes and Epigenetic Remodeling Are Barriers for Generating Transgene-Free Induced Pluripotent Stem Cells in Pig

• Kwang-Hwan Choi ,

  ¶‡ These authors are co-first authors on this work.

  Affiliation Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute of Agriculture and Life Science, Seoul National University, Seoul, Korea

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• Jin-Kyu Park ,

  ¶‡ These authors are co-first authors on this work.

  Affiliation Division of Animal Sciences and Bond Life Sciences Center, University of Missouri, Columbia, Missouri, United States of America

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• Dongchan Son,

  Affiliation Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute of Agriculture and Life Science, Seoul National University, Seoul, Korea

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• Jae Yeon Hwang,

  Current address: Department of Animal Life Science, Kangwon National University, Chuncheon, Republic of Korea

  Affiliation Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute of Agriculture and Life Science, Seoul National University, Seoul, Korea

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• Dong-Kyung Lee,

  Affiliation Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute of Agriculture and Life Science, Seoul National University, Seoul, Korea

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• Hakhyun Ka,

  Affiliation Department of Biological Resources and Technology, Yonsei University, Wonju, Korea

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• Joonghoon Park,

  Affiliation LG Life Sciences, R&D Park, Daejeon, Republic of Korea

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• Chang-Kyu Lee

  * E-mail: leeck@snu.ac.kr

  Affiliations Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute of Agriculture and Life Science, Seoul National University, Seoul, Korea, Institute of Green Bio Science and Technology, Seoul National University, Pyeong Chang, Kangwon do, Korea

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