Mutation in the Pro-Peptide Region of a Cysteine Protease Leads to Altered Activity and Specificity—A Structural and Biochemical Approach

Open Access

Peer-reviewed

Research Article

Sruti Dutta,

Affiliation Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata, 700 064, India
⨯
Debi Choudhury,

Affiliation Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata, 700 064, India
⨯
Sumana Roy,

Affiliation Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata, 700 064, India
⨯
Jiban Kanti Dattagupta,

Affiliation Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata, 700 064, India
⨯
Sampa Biswas

* E-mail: sampa.biswas@saha.ac.in

Affiliation Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata, 700 064, India
⨯

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Proteases
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Cysteine proteases
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Zymogens
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Crystal structure
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Enzyme structure
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Point mutation
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Enzymes
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Enzyme kinetics
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