The Integration of Epistasis Network and Functional Interactions in a GWAS Implicates RXR Pathway Genes in the Immune Response to Smallpox Vaccine

Open Access

Peer-reviewed

Research Article

Brett A. McKinney,

Affiliation Tandy School of Computer Science and Department of Mathematics, University of Tulsa, Tulsa, OK, United States of America
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Caleb Lareau,

Affiliation Tandy School of Computer Science and Department of Mathematics, University of Tulsa, Tulsa, OK, United States of America
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Ann L. Oberg,

Affiliation Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, United States of America
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Richard B. Kennedy,

Affiliation Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, United States of America
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Inna G. Ovsyannikova,

Affiliation Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, United States of America
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Gregory A. Poland

* E-mail: poland.gregory@mayo.edu

Affiliation Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, United States of America
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Epistasis
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Vaccines
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Genetic networks
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Immune response
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Smallpox
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Genome-wide association studies
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Centrality
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Interaction networks
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