Dissociation Dynamics of XPC-RAD23B from Damaged DNA Is a Determining Factor of NER Efficiency

Benjamin Hilton; Sathyaraj Gopal; Lifang Xu; Sharmistha Mazumder; Phillip R. Musich; Bongsup P. Cho; Yue Zou

doi:10.1371/journal.pone.0157784

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Open Access

Peer-reviewed

Research Article

Dissociation Dynamics of XPC-RAD23B from Damaged DNA Is a Determining Factor of NER Efficiency

Benjamin Hilton ,

Contributed equally to this work with: Benjamin Hilton, Sathyaraj Gopal

Affiliation Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, 37614, United States of America
⨯
Sathyaraj Gopal ,

Contributed equally to this work with: Benjamin Hilton, Sathyaraj Gopal

Affiliation Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, 02881, United States of America
⨯
Lifang Xu,

Affiliation Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, 02881, United States of America
⨯
Sharmistha Mazumder,

Affiliation Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, 37614, United States of America
⨯
Phillip R. Musich,

Affiliation Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, 37614, United States of America
⨯
Bongsup P. Cho ,

* E-mail: zouy@etsu.edu (YZ); bcho@uri.edu (BPC)

Affiliation Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, 02881, United States of America
⨯
Yue Zou

* E-mail: zouy@etsu.edu (YZ); bcho@uri.edu (BPC)

Affiliation Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, 37614, United States of America
⨯

Dissociation Dynamics of XPC-RAD23B from Damaged DNA Is a Determining Factor of NER Efficiency

Benjamin Hilton,
Sathyaraj Gopal,
Lifang Xu,
Sharmistha Mazumder,
Phillip R. Musich,
Bongsup P. Cho,
Yue Zou

Published: June 21, 2016
https://doi.org/10.1371/journal.pone.0157784

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DNA damage
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DNA-binding proteins
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DNA repair
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Chemical dissociation
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Electrophoretic mobility shift assay
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Protein interactions
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Thermodynamics
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Curve fitting
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