Ancient Haplotypes at the 15q24.2 Microdeletion Region Are Linked to Brain Expression of MAN2C1 and Children's Intelligence

• Alejandro Cáceres ,

  * E-mail: acaceres@creal.cat (AC); jrgonzalez@creal.cat (JRG)

  Affiliations ISGlobal, Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain, Universitat Pompeu Fabra, Barcelona, Spain, Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Madrid, Spain

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• Tõnu Esko,

  Affiliations Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America, Division of Endocrinology, Children’s Hospital Boston, Boston, Massachusetts, United States of America, Estonian Genome Center, University of Tartu, Tartu, Estonia

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• Irene Pappa,

  Affiliations School of Pedagogical and Educational Sciences, Erasmus University Rotterdam, Rotterdam, The Netherlands, Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands

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• Armand Gutiérrez,

  Affiliations Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain, Hospital del Mar Research Institute (IMIM), Barcelona, Spain

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• Maria-Jose Lopez-Espinosa,

  Affiliations Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Madrid, Spain, Epidemiology and Environmental Health Joint Research Unit, FISABIO–Universitat Jaume I–Universitat de València, Valencia, Spain

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• Sabrina Llop,

  Affiliations Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Madrid, Spain, Epidemiology and Environmental Health Joint Research Unit, FISABIO–Universitat Jaume I–Universitat de València, Valencia, Spain

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• Mariona Bustamante,

  Affiliations ISGlobal, Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain, Universitat Pompeu Fabra, Barcelona, Spain, Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Madrid, Spain, Genomics and Disease Group, Centre for Genomic Regulation (CRG), Barcelona, Spain

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• Henning Tiemeier,

  Affiliations Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center-Sophia Children’s Hospital, Rotterdam, The Netherlands, Department of Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands

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• Andres Metspalu,

  Affiliations Estonian Genome Center, University of Tartu, Tartu, Estonia, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia

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• Peter K. Joshi,

  Affiliation Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland

  http://orcid.org/0000-0002-6361-5059

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• James F. Wilsonx,

  Affiliations Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland

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• Judith Reina-Castillón,

  Affiliations Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain, Hospital del Mar Research Institute (IMIM), Barcelona, Spain

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• Jean Shin,

  Affiliation Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

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• Zdenka Pausova,

  Affiliation Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

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• Tomáš Paus,

  Affiliation Rotman Research Institute, University of Toronto, Toronto, Ontario, Canada

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• Jordi Sunyer,

  Affiliations ISGlobal, Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain, Universitat Pompeu Fabra, Barcelona, Spain, Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Madrid, Spain, Hospital del Mar Research Institute (IMIM), Barcelona, Spain

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• Luis A. Pérez-Jurado ,

  ¶‡ These authors are co-senior authors.

  Affiliations Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain, Hospital del Mar Research Institute (IMIM), Barcelona, Spain

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•  [ ... ],
• Juan R. González

  * E-mail: acaceres@creal.cat (AC); jrgonzalez@creal.cat (JRG)

  ¶‡ These authors are co-senior authors.

  Affiliations ISGlobal, Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain, Universitat Pompeu Fabra, Barcelona, Spain, Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Madrid, Spain, Department of Mathematics, Universitat Autònoma de Barcelona, Bellaterra (Barcelona), Spain

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