Autophagy and Mitochondrial Dysfunction in Tenon Fibroblasts from Exfoliation Glaucoma Patients

Andrew Want; Stephanie R. Gillespie; Zheng Wang; Ronald Gordon; Carlo Iomini; Robert Ritch; J. Mario Wolosin; Audrey M. Bernstein

doi:10.1371/journal.pone.0157404

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Peer-reviewed

Research Article

Autophagy and Mitochondrial Dysfunction in Tenon Fibroblasts from Exfoliation Glaucoma Patients

Andrew Want,

Affiliation Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States of America
⨯
Stephanie R. Gillespie,

Affiliations Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States of America, Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States of America
⨯
Zheng Wang,

Affiliation Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States of America
⨯
Ronald Gordon,

Affiliation Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States of America
⨯
Carlo Iomini,

Affiliation Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States of America
⨯
Robert Ritch,

Affiliation Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, 10003, United States of America
⨯
J. Mario Wolosin ,

* E-mail: audrey.bernstein@mssm.edu (AMB); jmario.wolosin@mssm.edu (JMW)

Affiliation Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States of America
⨯
Audrey M. Bernstein

* E-mail: audrey.bernstein@mssm.edu (AMB); jmario.wolosin@mssm.edu (JMW)

Affiliations Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States of America, Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States of America
⨯

Autophagy and Mitochondrial Dysfunction in Tenon Fibroblasts from Exfoliation Glaucoma Patients

Andrew Want,
Stephanie R. Gillespie,
Zheng Wang,
Ronald Gordon,
Carlo Iomini,
Robert Ritch,
J. Mario Wolosin,
Audrey M. Bernstein

Published: July 8, 2016
https://doi.org/10.1371/journal.pone.0157404

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Lysosomes
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Mitochondria
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Extracellular matrix proteins
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Glaucoma
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Light scattering
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Fibroblasts
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