Differential Activation in Amygdala and Plasma Noradrenaline during Colorectal Distention by Administration of Corticotropin-Releasing Hormone between Healthy Individuals and Patients with Irritable Bowel Syndrome

Yukari Tanaka; Motoyori Kanazawa; Michiko Kano; Joe Morishita; Toyohiro Hamaguchi; Lukas Van Oudenhove; Huynh Giao Ly; Patrick Dupont; Jan Tack; Takuhiro Yamaguchi; Kazuhiko Yanai; Manabu Tashiro; Shin Fukudo

doi:10.1371/journal.pone.0157347

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Open Access

Peer-reviewed

Research Article

Differential Activation in Amygdala and Plasma Noradrenaline during Colorectal Distention by Administration of Corticotropin-Releasing Hormone between Healthy Individuals and Patients with Irritable Bowel Syndrome

Yukari Tanaka,

Affiliations Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan, Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Motoyori Kanazawa,

Affiliation Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Michiko Kano,

Affiliations Department of Frontier Research Institute for Interdisciplinary Sciences, Tohoku University Graduate School of Medicine, Sendai, Japan, Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Joe Morishita,

Affiliation Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Toyohiro Hamaguchi,

Affiliation Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Lukas Van Oudenhove,

Affiliation Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Clinical & Experimental Medicine, KU Leuven, Leuven, Belgium
⨯
Huynh Giao Ly,

Affiliation Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Clinical & Experimental Medicine, KU Leuven, Leuven, Belgium
⨯
Patrick Dupont,

Affiliation Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium
⨯
Jan Tack,

Affiliation Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Clinical & Experimental Medicine, KU Leuven, Leuven, Belgium
⨯
Takuhiro Yamaguchi,

Affiliation Departments of Biostatistics, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Kazuhiko Yanai,

Affiliations Departments of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan, Departments of Cyclotron RI Center, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Manabu Tashiro,

Affiliation Departments of Cyclotron RI Center, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Shin Fukudo

* E-mail: sfukudo@med.tohoku.ac.jp

Affiliation Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯

Differential Activation in Amygdala and Plasma Noradrenaline during Colorectal Distention by Administration of Corticotropin-Releasing Hormone between Healthy Individuals and Patients with Irritable Bowel Syndrome

Yukari Tanaka,
Motoyori Kanazawa,
Michiko Kano,
Joe Morishita,
Toyohiro Hamaguchi,
Lukas Van Oudenhove,
Huynh Giao Ly,
Patrick Dupont,
Jan Tack,
Takuhiro Yamaguchi

Published: July 22, 2016
https://doi.org/10.1371/journal.pone.0157347

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