Blocking TGF-β Signaling Pathway Preserves Mitochondrial Proteostasis and Reduces Early Activation of PDGFRβ+ Pericytes in Aristolochic Acid Induced Acute Kidney Injury in Wistar Male Rats

Agnieszka A. Pozdzik; Laetitia Giordano; Gang Li; Marie-Hélène Antoine; Nathalie Quellard; Julie Godet; Eric De Prez; Cécile Husson; Anne-Emilie Declèves; Volker M. Arlt; Jean-Michel Goujon; Isabelle Brochériou-Spelle; Steven R. Ledbetter; Nathalie Caron; Joëlle L. Nortier

doi:10.1371/journal.pone.0157288

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Peer-reviewed

Research Article

Blocking TGF-β Signaling Pathway Preserves Mitochondrial Proteostasis and Reduces Early Activation of PDGFRβ+ Pericytes in Aristolochic Acid Induced Acute Kidney Injury in Wistar Male Rats

Agnieszka A. Pozdzik ,

* E-mail: agapozdzik@gmail.com

Affiliations Laboratory of Experimental Nephrology, Department of Biochemistry, Faculty of Medicine, ULB, Brussels, Belgium, Nephrology Department, Erasme Hospital, ULB, Brussels, Belgium
⨯
Laetitia Giordano,

Affiliation Laboratory of General Physiology, URPHYM, University of Namur, Namur, Belgium
⨯
Gang Li,

Affiliation CardioMetabolic and Renal Research, Cell Biology, Genzyme Corporation, Framingham, Massachusetts, United States of America
⨯
Marie-Hélène Antoine,

Affiliation Laboratory of Experimental Nephrology, Department of Biochemistry, Faculty of Medicine, ULB, Brussels, Belgium
⨯
Nathalie Quellard,

Affiliations Pathology and Electron Microscopy, CHU La Miletrie, Poitiers, France, INSERM U 1082, Poitiers, France
⨯
Julie Godet,

Affiliations Pathology and Electron Microscopy, CHU La Miletrie, Poitiers, France, INSERM U 1082, Poitiers, France
⨯
Eric De Prez,

Affiliation Laboratory of Experimental Nephrology, Department of Biochemistry, Faculty of Medicine, ULB, Brussels, Belgium
⨯
Cécile Husson,

Affiliation Laboratory of Experimental Nephrology, Department of Biochemistry, Faculty of Medicine, ULB, Brussels, Belgium
⨯
Anne-Emilie Declèves,

Affiliation Laboratory of General Physiology, URPHYM, University of Namur, Namur, Belgium
⨯
Volker M. Arlt,

Affiliation Analytical and Environmental Sciences Division, MRC-PHE Centre for Environment and Health, King’s College London, London, United Kingdom
⨯
Jean-Michel Goujon,

Affiliations Pathology and Electron Microscopy, CHU La Miletrie, Poitiers, France, INSERM U 1082, Poitiers, France
⨯
Isabelle Brochériou-Spelle,

Affiliation Pathology Department, Tenon Hospital, Paris, France
⨯
Steven R. Ledbetter,

Affiliation CardioMetabolic and Renal Research, Cell Biology, Genzyme Corporation, Framingham, Massachusetts, United States of America
⨯
Nathalie Caron,

Affiliation Laboratory of General Physiology, URPHYM, University of Namur, Namur, Belgium
⨯
Joëlle L. Nortier

Affiliations Laboratory of Experimental Nephrology, Department of Biochemistry, Faculty of Medicine, ULB, Brussels, Belgium, Nephrology Department, Erasme Hospital, ULB, Brussels, Belgium
⨯

Blocking TGF-β Signaling Pathway Preserves Mitochondrial Proteostasis and Reduces Early Activation of PDGFRβ+ Pericytes in Aristolochic Acid Induced Acute Kidney Injury in Wistar Male Rats

Agnieszka A. Pozdzik,
Laetitia Giordano,
Gang Li,
Marie-Hélène Antoine,
Nathalie Quellard,
Julie Godet,
Eric De Prez,
Cécile Husson,
Anne-Emilie Declèves,
Volker M. Arlt

Published: July 5, 2016
https://doi.org/10.1371/journal.pone.0157288

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