Trafficking Dynamics of PCSK9-Induced LDLR Degradation: Focus on Human PCSK9 Mutations and C-Terminal Domain

• Steve Poirier ,

  Contributed equally to this work with: Steve Poirier, Hocine Ait Hamouda

  ¶‡ These authors are co-first authors on this work.

  Affiliations Laboratory of Molecular Cell Biology, Montreal Heart Institute Research Center, QC, Canada, Département de Pharmacologie, Faculté de Médecine, Université de Montréal, QC, Canada

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• Hocine Ait Hamouda ,

  Contributed equally to this work with: Steve Poirier, Hocine Ait Hamouda

  ¶‡ These authors are co-first authors on this work.

  Affiliations Laboratory of Molecular Cell Biology, Montreal Heart Institute Research Center, QC, Canada, Département de Pharmacologie, Faculté de Médecine, Université de Montréal, QC, Canada

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• Louis Villeneuve,

  Affiliation Laboratory of Molecular Cell Biology, Montreal Heart Institute Research Center, QC, Canada

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• Annie Demers,

  Affiliation Laboratory of Molecular Cell Biology, Montreal Heart Institute Research Center, QC, Canada

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• Gaétan Mayer

  * E-mail: gaetan.mayer@icm-mhi.org

  Affiliations Laboratory of Molecular Cell Biology, Montreal Heart Institute Research Center, QC, Canada, Département de Pharmacologie, Faculté de Médecine, Université de Montréal, QC, Canada, Faculté de Pharmacie, Université de Montréal, QC, Canada

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