Exposure of Human CD4 T Cells to IL-12 Results in Enhanced TCR-Induced Cytokine Production, Altered TCR Signaling, and Increased Oxidative Metabolism

Aldo Vacaflores; Nicole M. Chapman; John T. Harty; Martin J. Richer; Jon C. D. Houtman

doi:10.1371/journal.pone.0157175

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Research Article

Exposure of Human CD4 T Cells to IL-12 Results in Enhanced TCR-Induced Cytokine Production, Altered TCR Signaling, and Increased Oxidative Metabolism

Aldo Vacaflores ,

Contributed equally to this work with: Aldo Vacaflores, Nicole M. Chapman, John T. Harty, Martin J. Richer, Jon C. D. Houtman

Affiliation Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America

http://orcid.org/0000-0003-0670-620X

⨯
Nicole M. Chapman ,

Contributed equally to this work with: Aldo Vacaflores, Nicole M. Chapman, John T. Harty, Martin J. Richer, Jon C. D. Houtman

Current address: Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

Affiliation Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America
⨯
John T. Harty ,

Contributed equally to this work with: Aldo Vacaflores, Nicole M. Chapman, John T. Harty, Martin J. Richer, Jon C. D. Houtman

Affiliations Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America, Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America, Department of Pathology, University of Iowa, Iowa City, Iowa, United States of America
⨯
Martin J. Richer ,

Contributed equally to this work with: Aldo Vacaflores, Nicole M. Chapman, John T. Harty, Martin J. Richer, Jon C. D. Houtman

Current address: Department of Microbiology and Immunology, Microbiome and Disease Tolerance Centre, McGill University, Montreal, Quebec, Canada

Affiliation Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Jon C. D. Houtman

Contributed equally to this work with: Aldo Vacaflores, Nicole M. Chapman, John T. Harty, Martin J. Richer, Jon C. D. Houtman

* E-mail: jon-houtman@uiowa.edu

Affiliations Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America, Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America, Department of Internal Medicine, Division of Immunology, University of Iowa, Iowa City, Iowa, United States of America
⨯

Exposure of Human CD4 T Cells to IL-12 Results in Enhanced TCR-Induced Cytokine Production, Altered TCR Signaling, and Increased Oxidative Metabolism

Aldo Vacaflores,
Nicole M. Chapman,
John T. Harty,
Martin J. Richer,
Jon C. D. Houtman

Published: June 9, 2016
https://doi.org/10.1371/journal.pone.0157175

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T helper cells
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T cells
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TCR signaling cascade
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