Use of a Conditional Ubr5 Mutant Allele to Investigate the Role of an N-End Rule Ubiquitin-Protein Ligase in Hedgehog Signalling and Embryonic Limb Development

Open Access

Peer-reviewed

Research Article

Elaine Kinsella,

Affiliation Edinburgh CRUK Cancer Research Centre, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh, UK
⨯
Natalie Dora,

Affiliation MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh, UK
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David Mellis,

Affiliation Edinburgh CRUK Cancer Research Centre, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh, UK
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Laura Lettice,

Affiliation MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh, UK
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Paul Deveney,

Affiliation MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh, UK
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Robert Hill ,

Contributed equally to this work with: Robert Hill, Mark Ditzel

Affiliation MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh, UK
⨯
Mark Ditzel

Contributed equally to this work with: Robert Hill, Mark Ditzel

* E-mail: mark.ditzel@ed.ac.uk

Affiliation Edinburgh CRUK Cancer Research Centre, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh, UK
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Hedgehog signaling
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Limb buds
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Embryos
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Heterozygosity
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Histology
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Embryonic pattern formation
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Chondrocytes
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Homozygosity
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