Topical Delivery of Tenofovir Disoproxil Fumarate and Emtricitabine from Pod-Intravaginal Rings Protects Macaques from Multiple SHIV Exposures

• Priya Srinivasan ,

  Contributed equally to this work with: Priya Srinivasan, John A. Moss

  Affiliation Laboratory Branch, Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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• John A. Moss ,

  Contributed equally to this work with: Priya Srinivasan, John A. Moss

  Affiliation Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America

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• Manjula Gunawardana,

  Affiliation Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America

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• Scott A. Churchman,

  Affiliation Auritec Pharmaceuticals, Inc., Pasadena, California, United States of America

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• Flora Yang,

  Affiliation Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America

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• Chuong T. Dinh,

  Affiliation Total Solutions, Inc., Atlanta, Georgia, United States of America

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• James M. Mitchell,

  Affiliation Laboratory Branch, Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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• Jining Zhang,

  Affiliation Total Solutions, Inc., Atlanta, Georgia, United States of America

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• Rob Fanter,

  Affiliation Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America

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• Christine S. Miller,

  Affiliation Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America

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• Irina Butkyavichene,

  Affiliation Auritec Pharmaceuticals, Inc., Pasadena, California, United States of America

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• Janet M. McNicholl,

  Affiliation Laboratory Branch, Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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• Thomas J. Smith,

  Affiliations Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America, Auritec Pharmaceuticals, Inc., Pasadena, California, United States of America

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• Marc M. Baum,

  Affiliation Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America

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• James M. Smith

  * E-mail: ajo9@cdc.gov

  Affiliation Laboratory Branch, Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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