A Common Ancestral Mutation in CRYBB3 Identified in Multiple Consanguineous Families with Congenital Cataracts

• Xiaodong Jiao ,

  Contributed equally to this work with: Xiaodong Jiao, Firoz Kabir, J. Fielding Hejtmancik, S. Amer Riazuddin

  Affiliation Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, United States of America

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• Firoz Kabir ,

  Contributed equally to this work with: Xiaodong Jiao, Firoz Kabir, J. Fielding Hejtmancik, S. Amer Riazuddin

  Affiliation The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, United States of America

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• Bushra Irum,

  Affiliations The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, United States of America, National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, 53700, Pakistan

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• Arif O. Khan,

  Affiliation King Khaled Eye Specialist Hospital, Riyadh, 12329, Saudi Arabia

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• Qiwei Wang,

  Affiliation Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, United States of America

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• David Li,

  Affiliation Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, United States of America

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• Asma A. Khan,

  Affiliation National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, 53700, Pakistan

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• Tayyab Husnain,

  Affiliation National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, 53700, Pakistan

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• Javed Akram,

  Affiliations Allama Iqbal Medical College, University of Health Sciences, Lahore, 54550, Pakistan, National Centre for Genetic Diseases, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan

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• Sheikh Riazuddin,

  Affiliations National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, 53700, Pakistan, Allama Iqbal Medical College, University of Health Sciences, Lahore, 54550, Pakistan, National Centre for Genetic Diseases, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan

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• J. Fielding Hejtmancik ,

  Contributed equally to this work with: Xiaodong Jiao, Firoz Kabir, J. Fielding Hejtmancik, S. Amer Riazuddin

  Affiliation Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, United States of America

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• S. Amer Riazuddin

  Contributed equally to this work with: Xiaodong Jiao, Firoz Kabir, J. Fielding Hejtmancik, S. Amer Riazuddin

  * E-mail: riazuddin@jhmi.edu

  Affiliation The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, United States of America

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