Mutations Designed by Ensemble Defect to Misfold Conserved RNA Structures of Influenza A Segments 7 and 8 Affect Splicing and Attenuate Viral Replication in Cell Culture

Open Access

Peer-reviewed

Research Article

Tian Jiang,

Affiliation Department of Chemistry, University of Rochester, Rochester, New York, United States of America
⨯
Aitor Nogales,

Affiliation Department of Microbiology and Immunology, University of Rochester, Rochester, New York, United States of America
⨯
Steven F Baker,

Affiliation Department of Microbiology and Immunology, University of Rochester, Rochester, New York, United States of America
⨯
Luis Martinez-Sobrido,

Affiliation Department of Microbiology and Immunology, University of Rochester, Rochester, New York, United States of America
⨯
Douglas H Turner

* E-mail: turner@chem.rochester.edu

Affiliation Department of Chemistry, University of Rochester, Rochester, New York, United States of America
⨯

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RNA structure
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Microbial mutation
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Influenza A virus
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Influenza
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Viral replication
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Viral vaccines
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Viral structure
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Pseudoknots
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