Distinct BOLD fMRI Responses of Capsaicin-Induced Thermal Sensation Reveal Pain-Related Brain Activation in Nonhuman Primates

Abu Bakar Ali Asad; Stephanie Seah; Richard Baumgartner; Dai Feng; Andres Jensen; Elaine Manigbas; Brian Henry; Andrea Houghton; Jeffrey L. Evelhoch; Stuart W. G. Derbyshire; Chih-Liang Chin

doi:10.1371/journal.pone.0156805

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Open Access

Peer-reviewed

Research Article

Distinct BOLD fMRI Responses of Capsaicin-Induced Thermal Sensation Reveal Pain-Related Brain Activation in Nonhuman Primates

Abu Bakar Ali Asad ,

* E-mail: asad.abu.bakar.ali@merck.com

Affiliation Translational Biomarkers, Merck Research Laboratories, MSD, Singapore, Singapore
⨯
Stephanie Seah,

Affiliation Translational Biomarkers, Merck Research Laboratories, MSD, Singapore, Singapore
⨯
Richard Baumgartner,

Affiliation Biometrics Research, Biostatistics & Research Decision Sciences, Merck Research Laboratories, Merck & Co., Rahway, NJ, United States of America
⨯
Dai Feng,

Affiliation Biometrics Research, Biostatistics & Research Decision Sciences, Merck Research Laboratories, Merck & Co., Rahway, NJ, United States of America
⨯
Andres Jensen,

Affiliation Early Discovery Pharmacology, Merck Research Laboratories, MSD, Singapore, Singapore
⨯
Elaine Manigbas,

Current address: Comparative Medicine Imaging Facility, National University of Singapore, Singapore, 117570, Singapore

Affiliation Imaging, Maccine Pte Ltd, Singapore, Singapore
⨯
Brian Henry,

Affiliation Early Discovery Pharmacology, Merck Research Laboratories, MSD, Singapore, Singapore
⨯
Andrea Houghton,

Affiliation Early Discovery Pharmacology, Merck Research Laboratories, Merck & Co., West Point, PA, United States of America
⨯
Jeffrey L. Evelhoch,

Affiliation Translational Biomarkers, Merck Research Laboratories, Merck & Co., West Point, PA, United States of America
⨯
Stuart W. G. Derbyshire,

Affiliations Dept of Psychology, National University of Singapore, Singapore, Singapore, A*STAR-NUS Clinical Imaging Research Centre, Singapore, Singapore
⨯
Chih-Liang Chin

Affiliation Translational Biomarkers, Merck Research Laboratories, MSD, Singapore, Singapore
⨯

Distinct BOLD fMRI Responses of Capsaicin-Induced Thermal Sensation Reveal Pain-Related Brain Activation in Nonhuman Primates

Abu Bakar Ali Asad,
Stephanie Seah,
Richard Baumgartner,
Dai Feng,
Andres Jensen,
Elaine Manigbas,
Brian Henry,
Andrea Houghton,
Jeffrey L. Evelhoch,
Stuart W. G. Derbyshire

Published: June 16, 2016
https://doi.org/10.1371/journal.pone.0156805

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