Alpha-Fetoprotein Detection of Hepatocellular Carcinoma Leads to a Standardized Analysis of Dynamic AFP to Improve Screening Based Detection

Thomas G. Bird; Polyxeni Dimitropoulou; Rebecca M. Turner; Sara J. Jenks; Pearce Cusack; Shiying Hey; Andrew Blunsum; Sarah Kelly; Catharine Sturgeon; Peter C. Hayes; Sheila M. Bird

doi:10.1371/journal.pone.0156801

Loading metrics

Open Access

Peer-reviewed

Research Article

Alpha-Fetoprotein Detection of Hepatocellular Carcinoma Leads to a Standardized Analysis of Dynamic AFP to Improve Screening Based Detection

Thomas G. Bird ,

* E-mail: t.bird@beatson.gla.ac.uk

Affiliations Centre for Liver and Digestive Disorders, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, United Kingdom, Cancer Research UK Beatson Institute, Glasgow, G61 1BD, United Kingdom

http://orcid.org/0000-0002-6120-1581

⨯
Polyxeni Dimitropoulou,

Affiliation MRC Biostatistics Unit, Cambridge, CB2 0SR, United Kingdom
⨯
Rebecca M. Turner,

Affiliation MRC Biostatistics Unit, Cambridge, CB2 0SR, United Kingdom
⨯
Sara J. Jenks,

Affiliation Department of Clinical Biochemistry, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, United Kingdom
⨯
Pearce Cusack,

Affiliation Centre for Liver and Digestive Disorders, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, United Kingdom

http://orcid.org/0000-0003-1879-274X

⨯
Shiying Hey,

Affiliation Centre for Liver and Digestive Disorders, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, United Kingdom
⨯
Andrew Blunsum,

Affiliation Centre for Liver and Digestive Disorders, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, United Kingdom
⨯
Sarah Kelly,

Affiliation Centre for Liver and Digestive Disorders, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, United Kingdom
⨯
Catharine Sturgeon,

Affiliation Department of Clinical Biochemistry, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, United Kingdom
⨯
Peter C. Hayes,

Affiliation Centre for Liver and Digestive Disorders, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, United Kingdom
⨯
Sheila M. Bird

Affiliations MRC Biostatistics Unit, Cambridge, CB2 0SR, United Kingdom, Department of Mathematics and Statistics, Strathclyde University, Glasgow, G1 1XH, United Kingdom
⨯

Alpha-Fetoprotein Detection of Hepatocellular Carcinoma Leads to a Standardized Analysis of Dynamic AFP to Improve Screening Based Detection

Thomas G. Bird,
Polyxeni Dimitropoulou,
Rebecca M. Turner,
Sara J. Jenks,
Pearce Cusack,
Shiying Hey,
Andrew Blunsum,
Sarah Kelly,
Catharine Sturgeon,
Peter C. Hayes

Published: June 16, 2016
https://doi.org/10.1371/journal.pone.0156801

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Hepatocellular carcinoma
Is the Subject Area "Hepatocellular carcinoma" applicable to this article?

Thanks for your feedback.
Etiology
Is the Subject Area "Etiology" applicable to this article?

Thanks for your feedback.
Bayesian method
Is the Subject Area "Bayesian method" applicable to this article?

Thanks for your feedback.
Liver transplantation
Is the Subject Area "Liver transplantation" applicable to this article?

Thanks for your feedback.
Lesions
Is the Subject Area "Lesions" applicable to this article?

Thanks for your feedback.
Algorithms
Is the Subject Area "Algorithms" applicable to this article?

Thanks for your feedback.
Liver diseases
Is the Subject Area "Liver diseases" applicable to this article?

Thanks for your feedback.
Disease surveillance
Is the Subject Area "Disease surveillance" applicable to this article?

Thanks for your feedback.