Discovery and Characterization of Phage Display-Derived Human Monoclonal Antibodies against RSV F Glycoprotein

Zhifeng Chen; Lan Zhang; Aimin Tang; Cheryl Callahan; Pavlo Pristatsky; Ryan Swoyer; Pedro Cejas; Debbie Nahas; Jennifer Galli; Scott Cosmi; Daniel DiStefano; Van M. Hoang; Andrew Bett; Danilo Casimiro; Kalpit A. Vora

doi:10.1371/journal.pone.0156798

Loading metrics

Open Access

Peer-reviewed

Research Article

Discovery and Characterization of Phage Display-Derived Human Monoclonal Antibodies against RSV F Glycoprotein

Zhifeng Chen ,

Contributed equally to this work with: Zhifeng Chen, Lan Zhang

Affiliation Department of Infectious Diseases and Vaccines Research, Merck Research Laboratories, Merck & Co., Inc., West Point, PA, United States of America
⨯
Lan Zhang ,

Contributed equally to this work with: Zhifeng Chen, Lan Zhang

Affiliation Department of Infectious Diseases and Vaccines Research, Merck Research Laboratories, Merck & Co., Inc., West Point, PA, United States of America
⨯
Aimin Tang,

Affiliation Department of Infectious Diseases and Vaccines Research, Merck Research Laboratories, Merck & Co., Inc., West Point, PA, United States of America
⨯
Cheryl Callahan,

Affiliation Department of Infectious Diseases and Vaccines Research, Merck Research Laboratories, Merck & Co., Inc., West Point, PA, United States of America
⨯
Pavlo Pristatsky,

Affiliation Vaccine Bioprocess Research and Development, Merck Research Laboratories, Merck & Co., Inc., West Point, PA, United States of America
⨯
Ryan Swoyer,

Affiliation Department of Infectious Diseases and Vaccines Research, Merck Research Laboratories, Merck & Co., Inc., West Point, PA, United States of America
⨯
Pedro Cejas,

Affiliation Department of Infectious Diseases and Vaccines Research, Merck Research Laboratories, Merck & Co., Inc., West Point, PA, United States of America
⨯
Debbie Nahas,

Affiliation Department of Infectious Diseases and Vaccines Research, Merck Research Laboratories, Merck & Co., Inc., West Point, PA, United States of America
⨯
Jennifer Galli,

Affiliation Department of Infectious Diseases and Vaccines Research, Merck Research Laboratories, Merck & Co., Inc., West Point, PA, United States of America
⨯
Scott Cosmi,

Affiliation Eurofins Lancaster Laboratories Professional Scientific Services, Lancaster, PA, United States of America
⨯
Daniel DiStefano,

Affiliation Department of Infectious Diseases and Vaccines Research, Merck Research Laboratories, Merck & Co., Inc., West Point, PA, United States of America
⨯
Van M. Hoang,

Affiliation Vaccine Bioprocess Research and Development, Merck Research Laboratories, Merck & Co., Inc., West Point, PA, United States of America
⨯
Andrew Bett,

Affiliation Department of Infectious Diseases and Vaccines Research, Merck Research Laboratories, Merck & Co., Inc., West Point, PA, United States of America
⨯
Danilo Casimiro,

Affiliation Department of Infectious Diseases and Vaccines Research, Merck Research Laboratories, Merck & Co., Inc., West Point, PA, United States of America
⨯
Kalpit A. Vora

* E-mail: kalpit.vora@merck.com

Affiliation Department of Infectious Diseases and Vaccines Research, Merck Research Laboratories, Merck & Co., Inc., West Point, PA, United States of America

http://orcid.org/0000-0001-9844-634X

⨯

Discovery and Characterization of Phage Display-Derived Human Monoclonal Antibodies against RSV F Glycoprotein

Zhifeng Chen,
Lan Zhang,
Aimin Tang,
Cheryl Callahan,
Pavlo Pristatsky,
Ryan Swoyer,
Pedro Cejas,
Debbie Nahas,
Jennifer Galli,
Scott Cosmi

Published: June 3, 2016
https://doi.org/10.1371/journal.pone.0156798

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Antibodies
Is the Subject Area "Antibodies" applicable to this article?

Thanks for your feedback.
Enzyme-linked immunoassays
Is the Subject Area "Enzyme-linked immunoassays" applicable to this article?

Thanks for your feedback.
Mutagenesis
Is the Subject Area "Mutagenesis" applicable to this article?

Thanks for your feedback.
Phage display
Is the Subject Area "Phage display" applicable to this article?

Thanks for your feedback.
Epitope mapping
Is the Subject Area "Epitope mapping" applicable to this article?

Thanks for your feedback.
Alanine
Is the Subject Area "Alanine" applicable to this article?

Thanks for your feedback.
Binding analysis
Is the Subject Area "Binding analysis" applicable to this article?

Thanks for your feedback.
Cell binding assay
Is the Subject Area "Cell binding assay" applicable to this article?

Thanks for your feedback.