Deep Sequencing Reveals Novel Genetic Variants in Children with Acute Liver Failure and Tissue Evidence of Impaired Energy Metabolism

C. Alexander Valencia; Xinjian Wang; Jin Wang; Anna Peters; Julia R. Simmons; Molly C. Moran; Abhinav Mathur; Ammar Husami; Yaping Qian; Rachel Sheridan; Kevin E. Bove; David Witte; Taosheng Huang; Alexander G. Miethke

doi:10.1371/journal.pone.0156738

Loading metrics

Open Access

Peer-reviewed

Research Article

Deep Sequencing Reveals Novel Genetic Variants in Children with Acute Liver Failure and Tissue Evidence of Impaired Energy Metabolism

C. Alexander Valencia ,

* E-mail: alexander.valencia@cchmc.org

Affiliations Divisions of Human Genetics, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229–3039, United States of America, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
⨯
Xinjian Wang,

Affiliation Divisions of Human Genetics, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229–3039, United States of America
⨯
Jin Wang,

Affiliation Divisions of Human Genetics, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229–3039, United States of America
⨯
Anna Peters,

Affiliation Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229–3039, United States of America
⨯
Julia R. Simmons,

Affiliation Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229–3039, United States of America
⨯
Molly C. Moran,

Affiliation Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229–3039, United States of America
⨯
Abhinav Mathur,

Affiliation Divisions of Human Genetics, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229–3039, United States of America
⨯
Ammar Husami,

Affiliation Divisions of Human Genetics, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229–3039, United States of America
⨯
Yaping Qian,

Affiliation Divisions of Human Genetics, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229–3039, United States of America
⨯
Rachel Sheridan,

Affiliation Pediatric Pathology, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229–3039, United States of America
⨯
Kevin E. Bove,

Affiliation Pediatric Pathology, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229–3039, United States of America
⨯
David Witte,

Affiliation Pediatric Pathology, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229–3039, United States of America
⨯
Taosheng Huang,

Affiliations Divisions of Human Genetics, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229–3039, United States of America, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
⨯
Alexander G. Miethke

Affiliations Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229–3039, United States of America, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
⨯

Deep Sequencing Reveals Novel Genetic Variants in Children with Acute Liver Failure and Tissue Evidence of Impaired Energy Metabolism

C. Alexander Valencia,
Xinjian Wang,
Jin Wang,
Anna Peters,
Julia R. Simmons,
Molly C. Moran,
Abhinav Mathur,
Ammar Husami,
Yaping Qian,
Rachel Sheridan

Published: August 2, 2016
https://doi.org/10.1371/journal.pone.0156738

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.
Fatty liver
Is the Subject Area "Fatty liver" applicable to this article?

Thanks for your feedback.
Mitochondrial DNA
Is the Subject Area "Mitochondrial DNA" applicable to this article?

Thanks for your feedback.
Hepatocytes
Is the Subject Area "Hepatocytes" applicable to this article?

Thanks for your feedback.
Heterozygosity
Is the Subject Area "Heterozygosity" applicable to this article?

Thanks for your feedback.
Frameshift mutation
Is the Subject Area "Frameshift mutation" applicable to this article?

Thanks for your feedback.
Next-generation sequencing
Is the Subject Area "Next-generation sequencing" applicable to this article?

Thanks for your feedback.
Histology
Is the Subject Area "Histology" applicable to this article?

Thanks for your feedback.