Critical Evaluation of P2X7 Receptor Antagonists in Selected Seizure Models

• Wolfgang Fischer ,

  * E-mail: fisw@medizin.uni-leipzig.de

  Affiliation Rudolf-Boehm-Institute of Pharmacology and Toxicology, Medical Faculty, University of Leipzig, Leipzig, Germany

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• Heike Franke,

  Affiliation Rudolf-Boehm-Institute of Pharmacology and Toxicology, Medical Faculty, University of Leipzig, Leipzig, Germany

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• Ute Krügel,

  Affiliation Rudolf-Boehm-Institute of Pharmacology and Toxicology, Medical Faculty, University of Leipzig, Leipzig, Germany

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• Heiko Müller,

  Affiliation Lead Discovery Center GmbH, Dortmund, Germany

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• Klaus Dinkel,

  Affiliations Lead Discovery Center GmbH, Dortmund, Germany, Affectis Pharmaceutical AG, Dortmund, Germany

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• Brian Lord,

  Affiliation Neuroscience Therapeutic Area, Janssen Research & Development, LLC, San Diego, California, United States of America

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• Michael A. Letavic,

  Affiliation Neuroscience Therapeutic Area, Janssen Research & Development, LLC, San Diego, California, United States of America

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• David C. Henshall,

  Affiliation Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland

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• Tobias Engel

  Affiliation Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland

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