Chemical Modification of Influenza CD8+ T-Cell Epitopes Enhances Their Immunogenicity Regardless of Immunodominance

Sietske K. Rosendahl Huber; Jolien J. Luimstra; Josine van Beek; Rieuwert Hoppes; Ronald H. J. Jacobi; Marion Hendriks; Kim Kapteijn; Casper Ouwerkerk; Boris Rodenko; Huib Ovaa; Jørgen de Jonge

doi:10.1371/journal.pone.0156462

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Open Access

Peer-reviewed

Research Article

Chemical Modification of Influenza CD8+ T-Cell Epitopes Enhances Their Immunogenicity Regardless of Immunodominance

Sietske K. Rosendahl Huber ,

Contributed equally to this work with: Sietske K. Rosendahl Huber, Jolien J. Luimstra

Affiliation Centre for Infectious Disease Control (Cib), National Institute for Public Health and the Environment, Bilthoven, the Netherlands
⨯
Jolien J. Luimstra ,

Contributed equally to this work with: Sietske K. Rosendahl Huber, Jolien J. Luimstra

Affiliations Division of Cell Biology, Netherlands Cancer Institute, Amsterdam, the Netherlands, Institute for Chemical Immunology (ICI), Utrecht, the Netherlands
⨯
Josine van Beek,

Affiliation Centre for Infectious Disease Control (Cib), National Institute for Public Health and the Environment, Bilthoven, the Netherlands
⨯
Rieuwert Hoppes,

Affiliation Division of Cell Biology, Netherlands Cancer Institute, Amsterdam, the Netherlands
⨯
Ronald H. J. Jacobi,

Affiliation Centre for Infectious Disease Control (Cib), National Institute for Public Health and the Environment, Bilthoven, the Netherlands
⨯
Marion Hendriks,

Affiliation Centre for Infectious Disease Control (Cib), National Institute for Public Health and the Environment, Bilthoven, the Netherlands
⨯
Kim Kapteijn,

Affiliation Division of Cell Biology, Netherlands Cancer Institute, Amsterdam, the Netherlands
⨯
Casper Ouwerkerk,

Affiliation Division of Cell Biology, Netherlands Cancer Institute, Amsterdam, the Netherlands
⨯
Boris Rodenko,

Affiliation Division of Cell Biology, Netherlands Cancer Institute, Amsterdam, the Netherlands
⨯
Huib Ovaa,

Affiliations Division of Cell Biology, Netherlands Cancer Institute, Amsterdam, the Netherlands, Institute for Chemical Immunology (ICI), Utrecht, the Netherlands
⨯
Jørgen de Jonge

* E-mail: jorgen.de.jonge@rivm.nl

Affiliation Centre for Infectious Disease Control (Cib), National Institute for Public Health and the Environment, Bilthoven, the Netherlands
⨯

Chemical Modification of Influenza CD8+ T-Cell Epitopes Enhances Their Immunogenicity Regardless of Immunodominance

Sietske K. Rosendahl Huber,
Jolien J. Luimstra,
Josine van Beek,
Rieuwert Hoppes,
Ronald H. J. Jacobi,
Marion Hendriks,
Kim Kapteijn,
Casper Ouwerkerk,
Boris Rodenko,
Huib Ovaa

Published: June 22, 2016
https://doi.org/10.1371/journal.pone.0156462

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