Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms

Angela M. Mabb; Jeremy M. Simon; Ian F. King; Hyeong-Min Lee; Lin-Kun An; Benjamin D. Philpot; Mark J. Zylka

doi:10.1371/journal.pone.0156439

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Open Access

Peer-reviewed

Research Article

Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms

Angela M. Mabb,

Affiliations Department of Cell Biology and Physiology, UNC Neuroscience Center, Carolina Institute for Developmental Disabilities, The University of North Carolina, Chapel Hill, North Carolina, United States of America, Neuroscience Institute, Georgia State University, Atlanta, Georgia, United States of America
⨯
Jeremy M. Simon,

Affiliation Department of Cell Biology and Physiology, UNC Neuroscience Center, Carolina Institute for Developmental Disabilities, The University of North Carolina, Chapel Hill, North Carolina, United States of America
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Ian F. King,

Affiliation Department of Cell Biology and Physiology, UNC Neuroscience Center, Carolina Institute for Developmental Disabilities, The University of North Carolina, Chapel Hill, North Carolina, United States of America
⨯
Hyeong-Min Lee,

Affiliation Department of Cell Biology and Physiology, UNC Neuroscience Center, Carolina Institute for Developmental Disabilities, The University of North Carolina, Chapel Hill, North Carolina, United States of America
⨯
Lin-Kun An,

Affiliation School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
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Benjamin D. Philpot ,

* E-mail: bphilpot@med.unc.edu (BDP); zylka@med.unc.edu (MJK)

Affiliation Department of Cell Biology and Physiology, UNC Neuroscience Center, Carolina Institute for Developmental Disabilities, The University of North Carolina, Chapel Hill, North Carolina, United States of America
⨯
Mark J. Zylka

* E-mail: bphilpot@med.unc.edu (BDP); zylka@med.unc.edu (MJK)

Affiliation Department of Cell Biology and Physiology, UNC Neuroscience Center, Carolina Institute for Developmental Disabilities, The University of North Carolina, Chapel Hill, North Carolina, United States of America
⨯

Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms

Angela M. Mabb,
Jeremy M. Simon,
Ian F. King,
Hyeong-Min Lee,
Lin-Kun An,
Benjamin D. Philpot,
Mark J. Zylka

Published: May 27, 2016
https://doi.org/10.1371/journal.pone.0156439

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Neurons
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Gene expression
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Cloning
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Immediate early genes
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DNA transcription
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Transfection
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Actins
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Gene regulation
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