Discovery of Novel Orally Active Tetrahydro-Naphthyl-N-Acylhydrazones with In Vivo Anti-TNF-α Effect and Remarkable Anti-Inflammatory Properties

• Natália M. Cordeiro,

  Affiliations Federal University of Rio de Janeiro, Institute of Biomedical Science, Laboratory of Pharmacology of Pain and Inflammation, Rio de Janeiro, Brazil, Federal University of Rio de Janeiro, Institute of Biomedical Science, Graduate Programm in Pharmacology and Medicinal Chemistry, Rio de Janeiro, Brazil

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• Rosana H. C. N. Freitas,

  Affiliations Federal University of Rio de Janeiro, Institute of Biomedical Science, Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), Rio de Janeiro, Brazil, Federal University of Rio de Janeiro, Chemistry Institute, Graduate Programm in Chemistry, Rio de Janeiro, Brazil

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• Carlos A. M. Fraga,

  Affiliations Federal University of Rio de Janeiro, Institute of Biomedical Science, Graduate Programm in Pharmacology and Medicinal Chemistry, Rio de Janeiro, Brazil, Federal University of Rio de Janeiro, Institute of Biomedical Science, Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), Rio de Janeiro, Brazil, Federal University of Rio de Janeiro, Chemistry Institute, Graduate Programm in Chemistry, Rio de Janeiro, Brazil

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• Patricia D. Fernandes

  * E-mail: patricia.dias@icb.ufrj.br

  Affiliations Federal University of Rio de Janeiro, Institute of Biomedical Science, Laboratory of Pharmacology of Pain and Inflammation, Rio de Janeiro, Brazil, Federal University of Rio de Janeiro, Institute of Biomedical Science, Graduate Programm in Pharmacology and Medicinal Chemistry, Rio de Janeiro, Brazil

  http://orcid.org/0000-0001-6870-6745

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