Crystal Structure of the FERM-SH2 Module of Human Jak2

Open Access

Peer-reviewed

Research Article

Randall McNally,

Affiliations Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
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Angela V. Toms,

Current address: Forma Therapeutics, Watertown, Massachusetts, United States of America

Affiliations Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Michael J. Eck

* E-mail: eck@crystal.harvard.edu

Affiliations Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
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SH2 domains
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Crystal structure
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Cytokine receptors
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Molecular structure
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Salt bridges
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Hydrogen bonding
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Tyrosine kinases
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Point mutation
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