Inhibition of Cardiac Kir Current (IK1) by Protein Kinase C Critically Depends on PKCβ and Kir2.2

Daniel Scherer; Claudia Seyler; Panagiotis Xynogalos; Eberhard P. Scholz; Dierk Thomas; Johannes Backs; Martin Andrassy; Mirko Völkers; Christoph A. Karle; Hugo A. Katus; Edgar Zitron

doi:10.1371/journal.pone.0156181

Loading metrics

Open Access

Peer-reviewed

Research Article

Inhibition of Cardiac Kir Current (I_K1) by Protein Kinase C Critically Depends on PKCβ and Kir2.2

Daniel Scherer ,

* E-mail: daniel.scherer@med.uni-heidelberg.de

Affiliation Department of Cardiology, Medical University Hospital Heidelberg, Heidelberg, Germany
⨯
Claudia Seyler,

Affiliation Department of Cardiology, Medical University Hospital Heidelberg, Heidelberg, Germany
⨯
Panagiotis Xynogalos,

Affiliation Department of Cardiology, Medical University Hospital Heidelberg, Heidelberg, Germany
⨯
Eberhard P. Scholz,

Affiliation Department of Cardiology, Medical University Hospital Heidelberg, Heidelberg, Germany
⨯
Dierk Thomas,

Affiliations Department of Cardiology, Medical University Hospital Heidelberg, Heidelberg, Germany, DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany
⨯
Johannes Backs,

Affiliations Department of Cardiology, Medical University Hospital Heidelberg, Heidelberg, Germany, DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany
⨯
Martin Andrassy,

Affiliation Department of Cardiology, Medical University Hospital Heidelberg, Heidelberg, Germany
⨯
Mirko Völkers,

Affiliations Department of Cardiology, Medical University Hospital Heidelberg, Heidelberg, Germany, DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany
⨯
Christoph A. Karle,

Affiliation Department of Cardiology, Medical University Hospital Heidelberg, Heidelberg, Germany
⨯
Hugo A. Katus,

Affiliations Department of Cardiology, Medical University Hospital Heidelberg, Heidelberg, Germany, DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany
⨯
Edgar Zitron

Affiliations Department of Cardiology, Medical University Hospital Heidelberg, Heidelberg, Germany, DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany
⨯

Inhibition of Cardiac Kir Current (I_K1) by Protein Kinase C Critically Depends on PKCβ and Kir2.2

Daniel Scherer,
Claudia Seyler,
Panagiotis Xynogalos,
Eberhard P. Scholz,
Dierk Thomas,
Johannes Backs,
Martin Andrassy,
Mirko Völkers,
Christoph A. Karle,
Hugo A. Katus

Published: May 23, 2016
https://doi.org/10.1371/journal.pone.0156181

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cardiomyocytes
Is the Subject Area "Cardiomyocytes" applicable to this article?

Thanks for your feedback.
Protein kinases
Is the Subject Area "Protein kinases" applicable to this article?

Thanks for your feedback.
Xenopus oocytes
Is the Subject Area "Xenopus oocytes" applicable to this article?

Thanks for your feedback.
Signal inhibition
Is the Subject Area "Signal inhibition" applicable to this article?

Thanks for your feedback.
Membrane potential
Is the Subject Area "Membrane potential" applicable to this article?

Thanks for your feedback.
Tachycardia
Is the Subject Area "Tachycardia" applicable to this article?

Thanks for your feedback.
Phospholipases
Is the Subject Area "Phospholipases" applicable to this article?

Thanks for your feedback.
Drug regulation
Is the Subject Area "Drug regulation" applicable to this article?

Thanks for your feedback.