IGF-1 and Chondroitinase ABC Augment Nerve Regeneration after Vascularized Composite Limb Allotransplantation

Nataliya V. Kostereva; Yong Wang; Derek R. Fletcher; Jignesh V. Unadkat; Jonas T. Schnider; Chiaki Komatsu; Yang Yang; Donna B. Stolz; Michael R. Davis; Jan A. Plock; Vijay S. Gorantla

doi:10.1371/journal.pone.0156149

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Open Access

Peer-reviewed

Research Article

IGF-1 and Chondroitinase ABC Augment Nerve Regeneration after Vascularized Composite Limb Allotransplantation

Nataliya V. Kostereva,

Affiliations Department of Plastic Surgery, Thomas E. Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Yong Wang,

Affiliations Department of Plastic Surgery, Thomas E. Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Trauma Surgery, East Hospital of Shanghai, Shanghai, China
⨯
Derek R. Fletcher,

Current address: Division of Plastic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Affiliation Department of Plastic Surgery, Thomas E. Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Jignesh V. Unadkat,

Affiliation Department of Plastic Surgery, Thomas E. Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Jonas T. Schnider,

Current address: Department of Plastic and Hand Surgery, Inselspital, University Hospital Bern, Bern, Switzerland

Affiliation Department of Plastic Surgery, Thomas E. Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Chiaki Komatsu,

Affiliation Department of Plastic Surgery, Thomas E. Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Yang Yang,

Current address: Department of Plastic and Reconstructive Surgery, Xijing Hospital, Forth Military Medical University, Shaanxi, Xi'an, Xincheng, China

Affiliation Department of Plastic Surgery, Thomas E. Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Donna B. Stolz,

Affiliation Center for Biological Imaging, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Michael R. Davis,

Affiliation United States Army Institute for Surgical Research, San Antonio Military Medical Center, 3698 Chambers Road, San Antonio, Texas, United States of America
⨯
Jan A. Plock,

Current address: Division of Plastic and Hand Surgery, University Hospital Zurich, Zurich, Switzerland

Affiliations Department of Plastic Surgery, Thomas E. Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Vijay S. Gorantla

* E-mail: gorantlavs@upmc.edu

Affiliations Department of Plastic Surgery, Thomas E. Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯

IGF-1 and Chondroitinase ABC Augment Nerve Regeneration after Vascularized Composite Limb Allotransplantation

Nataliya V. Kostereva,
Yong Wang,
Derek R. Fletcher,
Jignesh V. Unadkat,
Jonas T. Schnider,
Chiaki Komatsu,
Yang Yang,
Donna B. Stolz,
Michael R. Davis,
Jan A. Plock

Published: June 7, 2016
https://doi.org/10.1371/journal.pone.0156149

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