Multi-Compartmentalisation in the MAPK Signalling Pathway Contributes to the Emergence of Oscillatory Behaviour and to Ultrasensitivity

Open Access

Peer-reviewed

Research Article

Aban Shuaib,

Affiliations Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom, Department of Computer Science, University of Sheffield, Sheffield, United Kingdom, INSIGNEO Institute for in silico Medicine, University of Sheffield, Sheffield, United Kingdom
⨯
Adam Hartwell,

Affiliation Department of Automatic Control and Systems Engineering, University of Sheffield, Sheffield, United Kingdom
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Endre Kiss-Toth ,

¶‡ These authors share senior responsibility for this study.

Affiliation Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom
⨯
Mike Holcombe

* E-mail: m.holcombe@sheffield.ac.uk

¶‡ These authors share senior responsibility for this study.

Affiliations Department of Computer Science, University of Sheffield, Sheffield, United Kingdom, Advanced Computing Research Centre, The Sheffield Bioincubator, University of Sheffield, Sheffield, United Kingdom
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MAPK signaling cascades
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Protein kinase signaling cascade
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Cytoplasm
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Agent-based modeling
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Genetic oscillators
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Two-compartment models
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ERK signaling cascade
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Signal processing
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