Mouse and Human CD1d-Self-Lipid Complexes Are Recognized Differently by Murine Invariant Natural Killer T Cell Receptors

Tingxi Guo; Kenji Chamoto; Munehide Nakatsugawa; Toshiki Ochi; Yuki Yamashita; Mark Anczurowski; Marcus O. Butler; Naoto Hirano

doi:10.1371/journal.pone.0156114

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Open Access

Peer-reviewed

Research Article

Mouse and Human CD1d-Self-Lipid Complexes Are Recognized Differently by Murine Invariant Natural Killer T Cell Receptors

Tingxi Guo,

Affiliations Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada, Department of Immunology, University of Toronto, Toronto, Ontario, Canada
⨯
Kenji Chamoto,

Affiliation Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada
⨯
Munehide Nakatsugawa,

Affiliation Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada
⨯
Toshiki Ochi,

Affiliation Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada
⨯
Yuki Yamashita,

Affiliation Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada
⨯
Mark Anczurowski,

Affiliations Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada, Department of Immunology, University of Toronto, Toronto, Ontario, Canada
⨯
Marcus O. Butler,

Affiliations Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada, Department of Immunology, University of Toronto, Toronto, Ontario, Canada, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
⨯
Naoto Hirano

* E-mail: naoto.hirano@utoronto.ca

Affiliations Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada, Department of Immunology, University of Toronto, Toronto, Ontario, Canada
⨯

Mouse and Human CD1d-Self-Lipid Complexes Are Recognized Differently by Murine Invariant Natural Killer T Cell Receptors

Tingxi Guo,
Kenji Chamoto,
Munehide Nakatsugawa,
Toshiki Ochi,
Yuki Yamashita,
Mark Anczurowski,
Marcus O. Butler,
Naoto Hirano

Published: May 23, 2016
https://doi.org/10.1371/journal.pone.0156114

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Transfection
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Cloning
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T cell receptors
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T cells
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Lipids
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Cell staining
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Antigen-presenting cells
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Gene cloning
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