CRISPR-Mediated Slamf1Δ/Δ Slamf5Δ/Δ Slamf6Δ/Δ Triple Gene Disruption Reveals NKT Cell Defects but Not T Follicular Helper Cell Defects

Open Access

Peer-reviewed

Research Article

CRISPR-Mediated Slamf1^Δ/Δ Slamf5^Δ/Δ Slamf6^Δ/Δ Triple Gene Disruption Reveals NKT Cell Defects but Not T Follicular Helper Cell Defects

Joyce K. Hu,

Affiliation Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
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Jordan C. Crampton,

Affiliation Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
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Michela Locci,

Affiliation Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
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Shane Crotty

* E-mail: shane@lji.org (SC)

Affiliations Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America, Department of Medicine, University of California, San Diego School of Medicine, La Jolla, California, United States of America
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B cells
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Cytotoxic T cells
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B cell receptors
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T cell receptors
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Guide RNA
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T helper cells
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CD coreceptors
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T cells
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