Squamous Metaplasia Is Increased in the Bronchial Epithelium of Smokers with Chronic Obstructive Pulmonary Disease

Helen M. Rigden; Ahmad Alias; Thomas Havelock; Rory O'Donnell; Ratko Djukanovic; Donna E. Davies; Susan J. Wilson

doi:10.1371/journal.pone.0156009

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Open Access

Peer-reviewed

Research Article

Squamous Metaplasia Is Increased in the Bronchial Epithelium of Smokers with Chronic Obstructive Pulmonary Disease

Helen M. Rigden,

Affiliation Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⨯
Ahmad Alias,

Affiliation Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⨯
Thomas Havelock,

Affiliations Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton, Tremona Road, Southampton, United Kingdom
⨯
Rory O'Donnell,

Affiliation Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⨯
Ratko Djukanovic,

Affiliations Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton, Tremona Road, Southampton, United Kingdom
⨯
Donna E. Davies,

Affiliations Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton, Tremona Road, Southampton, United Kingdom
⨯
Susan J. Wilson

* E-mail: S.J.Wilson@southampton.ac.uk

Affiliation Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⨯

Squamous Metaplasia Is Increased in the Bronchial Epithelium of Smokers with Chronic Obstructive Pulmonary Disease

Helen M. Rigden,
Ahmad Alias,
Thomas Havelock,
Rory O'Donnell,
Ratko Djukanovic,
Donna E. Davies,
Susan J. Wilson

Published: May 26, 2016
https://doi.org/10.1371/journal.pone.0156009

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Epithelium
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Chronic obstructive pulmonary disease
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Cell differentiation
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Lung and intrathoracic tumors
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Immunohistochemistry techniques
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Phenotypes
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Smoking habits
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Biopsy
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