Exploring the Effects of Genetic Variants on Clinical Profiles of Parkinson’s Disease Assessed by the Unified Parkinson’s Disease Rating Scale and the Hoehn–Yahr Stage

• Chen Shi ,

  ¶‡ The first two authors contributed equally to this work.

  Affiliations Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China, Bioinformatics Center, School of Biomedical Engineering, Capital Medical University, Beijing, China

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• Zheng Zheng ,

  ¶‡ The first two authors contributed equally to this work.

  Affiliation Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China

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• Qi Wang,

  Affiliation Department of Statistics, Purdue University, West Lafayette, Indiana, United States of America

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• Chaodong Wang,

  Affiliations Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China, Department of Neurology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China, Department of Neurology, The Affiliated Sanming First Hospital of Fujian Medical University, Sanming, Fujian, China

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• Dabao Zhang,

  Affiliations Bioinformatics Center, School of Biomedical Engineering, Capital Medical University, Beijing, China, Department of Statistics, Purdue University, West Lafayette, Indiana, United States of America

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• Min Zhang ,

  * E-mail: zhangmin@ccmu.edu.cn (MZ); pbchan90@gmail.com (PC); xmwang@ccmu.edu.cn (XMW)

  Affiliations Bioinformatics Center, School of Biomedical Engineering, Capital Medical University, Beijing, China, Department of Statistics, Purdue University, West Lafayette, Indiana, United States of America, Alzheimer Disease Center of Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China

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• Piu Chan ,

  * E-mail: zhangmin@ccmu.edu.cn (MZ); pbchan90@gmail.com (PC); xmwang@ccmu.edu.cn (XMW)

  Affiliations Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China, Department of Neurology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China, Key Laboratory on Neurodegenerative Disease of Ministry of Education and Key Laboratory on Parkinson’s Disease of Beijing, Beijing, China, Parkinson Disease Center of Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China

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• Xiaomin Wang

  * E-mail: zhangmin@ccmu.edu.cn (MZ); pbchan90@gmail.com (PC); xmwang@ccmu.edu.cn (XMW)

  Affiliations Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China, Parkinson Disease Center of Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China

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