Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer

Bankanidhi Sahoo; Irene Arduini; Kenneth W. Drombosky; Ravindra Kodali; Laurie H. Sanders; J. Timothy Greenamyre; Ronald Wetzel

doi:10.1371/journal.pone.0155747

Loading metrics

Open Access

Peer-reviewed

Research Article

Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer

Bankanidhi Sahoo,

Affiliations Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America, Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America
⨯
Irene Arduini,

Affiliations Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America, Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America
⨯
Kenneth W. Drombosky,

Affiliations Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America, Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America
⨯
Ravindra Kodali,

Affiliations Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America, Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America
⨯
Laurie H. Sanders,

Affiliations Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America, Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America
⨯
J. Timothy Greenamyre,

Affiliations Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America, Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America
⨯
Ronald Wetzel

* E-mail: rwetzel@pitt.edu

Affiliations Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America, Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America
⨯

Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer

Bankanidhi Sahoo,
Irene Arduini,
Kenneth W. Drombosky,
Ravindra Kodali,
Laurie H. Sanders,
J. Timothy Greenamyre,
Ronald Wetzel

Published: June 6, 2016
https://doi.org/10.1371/journal.pone.0155747

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Amyloid proteins
Is the Subject Area "Amyloid proteins" applicable to this article?

Thanks for your feedback.
Monomers
Is the Subject Area "Monomers" applicable to this article?

Thanks for your feedback.
Autocorrelation
Is the Subject Area "Autocorrelation" applicable to this article?

Thanks for your feedback.
Oligomers
Is the Subject Area "Oligomers" applicable to this article?

Thanks for your feedback.
Dimers
Is the Subject Area "Dimers" applicable to this article?

Thanks for your feedback.
DNA damage
Is the Subject Area "DNA damage" applicable to this article?

Thanks for your feedback.
Fluorescence spectroscopy
Is the Subject Area "Fluorescence spectroscopy" applicable to this article?

Thanks for your feedback.
Toxicity
Is the Subject Area "Toxicity" applicable to this article?

Thanks for your feedback.