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Open Access
Peer-reviewed
Research Article
Boosting with Subtype C CN54rgp140 Protein Adjuvanted with Glucopyranosyl Lipid Adjuvant after Priming with HIV-DNA and HIV-MVA Is Safe and Enhances Immune Responses: A Phase I Trial
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Agricola Joachim ,
Contributed equally to this work with: Agricola Joachim, Asli Bauer
* E-mail: agricola.joachim@ki.se; agricolaj@yahoo.com
Affiliations Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
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Asli Bauer ,
Contributed equally to this work with: Agricola Joachim, Asli Bauer
Affiliations National Institute for Medical Research-Mbeya, Medical Research Center, Mbeya, Tanzania, Department of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (LMU), Munich, Germany
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Sarah Joseph,
Affiliation Medical Research Council Clinical Trials Unit, University College London, London, United Kingdom
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Christof Geldmacher,
Affiliations Department of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (LMU), Munich, Germany, German Center for Infection Research (DZIF), partner site Munich, Munich, Germany
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Patricia J. Munseri,
Affiliation Department of Internal Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
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Said Aboud,
Affiliation Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
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Marco Missanga,
Affiliation National Institute for Medical Research-Mbeya, Medical Research Center, Mbeya, Tanzania
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Philipp Mann,
Current address: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Affiliation National Institute for Medical Research-Mbeya, Medical Research Center, Mbeya, Tanzania
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Britta Wahren,
Affiliation Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
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Guido Ferrari,
Affiliation Department of Surgery and Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
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Victoria R. Polonis,
Affiliation The Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
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Merlin L. Robb,
Affiliations The Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, The Military HIV Research Program, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America
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Jonathan Weber,
Affiliation Imperial College London, London, United Kingdom
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Roger Tatoud,
Current address: International AIDS Vaccine Initiative (IAVI), St Stephen’s Centre, Chelsea & Westminster NHS Foundation Trust, London, United Kingdom
Affiliation Imperial College London, London, United Kingdom
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Leonard Maboko,
Affiliation National Institute for Medical Research-Mbeya, Medical Research Center, Mbeya, Tanzania
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Michael Hoelscher,
Affiliations National Institute for Medical Research-Mbeya, Medical Research Center, Mbeya, Tanzania, Department of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (LMU), Munich, Germany, German Center for Infection Research (DZIF), partner site Munich, Munich, Germany
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Eligius F. Lyamuya,
Affiliation Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
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Gunnel Biberfeld,
Affiliation Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
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Eric Sandström,
Affiliation Venhälsan, Karolinska Insitutet at Södersjukhuset, Stockholm, Sweden
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Arne Kroidl,
Affiliations National Institute for Medical Research-Mbeya, Medical Research Center, Mbeya, Tanzania, Department of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (LMU), Munich, Germany, German Center for Infection Research (DZIF), partner site Munich, Munich, Germany
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Muhammad Bakari,
Affiliation Department of Internal Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
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Charlotta Nilsson,
Affiliations Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden, The Public Health Agency of Sweden, Solna, Sweden, Department of Laboratory Medicine, Karolinska Institutet Huddinge, Stockholm, Sweden
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Sheena McCormack
Affiliation Medical Research Council Clinical Trials Unit, University College London, London, United Kingdom
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Boosting with Subtype C CN54rgp140 Protein Adjuvanted with Glucopyranosyl Lipid Adjuvant after Priming with HIV-DNA and HIV-MVA Is Safe and Enhances Immune Responses: A Phase I Trial
- Agricola Joachim,
- Asli Bauer,
- Sarah Joseph,
- Christof Geldmacher,
- Patricia J. Munseri,
- Said Aboud,
- Marco Missanga,
- Philipp Mann,
- Britta Wahren,
- Guido Ferrari
- Published: May 18, 2016
- https://doi.org/10.1371/journal.pone.0155702