Evaluation of a Mathematical Model of Rat Body Weight Regulation in Application to Caloric Restriction and Drug Treatment Studies

Jangir Selimkhanov; W. Clayton Thompson; Terrell A. Patterson; John R. Hadcock; Dennis O. Scott; Tristan S. Maurer; Cynthia J. Musante

doi:10.1371/journal.pone.0155674

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Peer-reviewed

Research Article

Evaluation of a Mathematical Model of Rat Body Weight Regulation in Application to Caloric Restriction and Drug Treatment Studies

Jangir Selimkhanov,

Affiliation Cardiovascular and Metabolic Diseases Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America
⨯
W. Clayton Thompson,

Affiliation Cardiovascular and Metabolic Diseases Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America
⨯
Terrell A. Patterson,

Current address: Rare Disease Clinical Sciences, Global Medicines Development, Pfizer Global Innovative Pharmaceuticals Business, Groton, Connecticut, United States of America

Affiliation Cardiovascular and Metabolic Diseases Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America
⨯
John R. Hadcock,

Current address: In Vivo Pharmacology, Cardiovascular and Metabolic Diseases, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Affiliation Cardiovascular and Metabolic Diseases Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America

http://orcid.org/0000-0001-9719-1189

⨯
Dennis O. Scott,

Affiliation Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America
⨯
Tristan S. Maurer,

Affiliation Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America
⨯
Cynthia J. Musante

* E-mail: cynthia.j.musante@pfizer.com

Affiliation Cardiovascular and Metabolic Diseases Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America
⨯

Evaluation of a Mathematical Model of Rat Body Weight Regulation in Application to Caloric Restriction and Drug Treatment Studies

Jangir Selimkhanov,
W. Clayton Thompson,
Terrell A. Patterson,
John R. Hadcock,
Dennis O. Scott,
Tristan S. Maurer,
Cynthia J. Musante

Published: May 26, 2016
https://doi.org/10.1371/journal.pone.0155674

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Body weight
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