Powerful Complex Immunoadjuvant Based on Synergistic Effect of Combined TLR4 and NOD2 Activation Significantly Enhances Magnitude of Humoral and Cellular Adaptive Immune Responses

Amir I. Tukhvatulin; Alina S. Dzharullaeva; Natalia M. Tukhvatulina; Dmitry V. Shcheblyakov; Maxim M. Shmarov; Inna V. Dolzhikova; Patricia Stanhope-Baker; Boris S. Naroditsky; Andrei V. Gudkov; Denis Y. Logunov; Alexander L. Gintsburg

doi:10.1371/journal.pone.0155650

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Open Access

Peer-reviewed

Research Article

Powerful Complex Immunoadjuvant Based on Synergistic Effect of Combined TLR4 and NOD2 Activation Significantly Enhances Magnitude of Humoral and Cellular Adaptive Immune Responses

Amir I. Tukhvatulin,

Affiliation N. F. Gamaleya Research Institute for Epidemiology and Microbiology, Gamaleya str.18, 123098 Moscow, Russia

http://orcid.org/0000-0001-8506-2339

⨯
Alina S. Dzharullaeva,

Affiliation N. F. Gamaleya Research Institute for Epidemiology and Microbiology, Gamaleya str.18, 123098 Moscow, Russia
⨯
Natalia M. Tukhvatulina,

Affiliation N. F. Gamaleya Research Institute for Epidemiology and Microbiology, Gamaleya str.18, 123098 Moscow, Russia
⨯
Dmitry V. Shcheblyakov,

Affiliation N. F. Gamaleya Research Institute for Epidemiology and Microbiology, Gamaleya str.18, 123098 Moscow, Russia
⨯
Maxim M. Shmarov,

Affiliation N. F. Gamaleya Research Institute for Epidemiology and Microbiology, Gamaleya str.18, 123098 Moscow, Russia
⨯
Inna V. Dolzhikova,

Affiliation N. F. Gamaleya Research Institute for Epidemiology and Microbiology, Gamaleya str.18, 123098 Moscow, Russia
⨯
Patricia Stanhope-Baker,

Affiliation Cleveland BioLabs, Inc., Buffalo, New York, United States of America
⨯
Boris S. Naroditsky,

Affiliation N. F. Gamaleya Research Institute for Epidemiology and Microbiology, Gamaleya str.18, 123098 Moscow, Russia
⨯
Andrei V. Gudkov,

Affiliations Cleveland BioLabs, Inc., Buffalo, New York, United States of America, Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton str., 14263 Buffalo, New York, United States of America
⨯
Denis Y. Logunov ,

* E-mail: ldenisy@yahoo.com

Affiliation N. F. Gamaleya Research Institute for Epidemiology and Microbiology, Gamaleya str.18, 123098 Moscow, Russia
⨯
Alexander L. Gintsburg

Affiliation N. F. Gamaleya Research Institute for Epidemiology and Microbiology, Gamaleya str.18, 123098 Moscow, Russia
⨯

Powerful Complex Immunoadjuvant Based on Synergistic Effect of Combined TLR4 and NOD2 Activation Significantly Enhances Magnitude of Humoral and Cellular Adaptive Immune Responses

Amir I. Tukhvatulin,
Alina S. Dzharullaeva,
Natalia M. Tukhvatulina,
Dmitry V. Shcheblyakov,
Maxim M. Shmarov,
Inna V. Dolzhikova,
Patricia Stanhope-Baker,
Boris S. Naroditsky,
Andrei V. Gudkov,
Denis Y. Logunov

Published: May 17, 2016
https://doi.org/10.1371/journal.pone.0155650

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