TGF-β Small Molecule Inhibitor SB431542 Reduces Rotator Cuff Muscle Fibrosis and Fatty Infiltration By Promoting Fibro/Adipogenic Progenitor Apoptosis

Michael R. Davies; Xuhui Liu; Lawrence Lee; Dominique Laron; Anne Y. Ning; Hubert T. Kim; Brian T. Feeley

doi:10.1371/journal.pone.0155486

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Peer-reviewed

Research Article

TGF-β Small Molecule Inhibitor SB431542 Reduces Rotator Cuff Muscle Fibrosis and Fatty Infiltration By Promoting Fibro/Adipogenic Progenitor Apoptosis

Michael R. Davies ,

Contributed equally to this work with: Michael R. Davies, Xuhui Liu

Affiliation Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, California, United States of America
⨯
Xuhui Liu ,

Contributed equally to this work with: Michael R. Davies, Xuhui Liu

Affiliations Department of Veterans Affairs, San Francisco Veterans Affairs Medical Center, San Francisco, California, United States of America, Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, California, United States of America
⨯
Lawrence Lee,

Affiliation Department of Veterans Affairs, San Francisco Veterans Affairs Medical Center, San Francisco, California, United States of America
⨯
Dominique Laron,

Affiliation Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, California, United States of America
⨯
Anne Y. Ning,

Affiliation Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, California, United States of America
⨯
Hubert T. Kim,

Affiliations Department of Veterans Affairs, San Francisco Veterans Affairs Medical Center, San Francisco, California, United States of America, Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, California, United States of America
⨯
Brian T. Feeley

* E-mail: feeleyb@orthosurg.ucsf.edu

Affiliations Department of Veterans Affairs, San Francisco Veterans Affairs Medical Center, San Francisco, California, United States of America, Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, California, United States of America
⨯

TGF-β Small Molecule Inhibitor SB431542 Reduces Rotator Cuff Muscle Fibrosis and Fatty Infiltration By Promoting Fibro/Adipogenic Progenitor Apoptosis

Michael R. Davies,
Xuhui Liu,
Lawrence Lee,
Dominique Laron,
Anne Y. Ning,
Hubert T. Kim,
Brian T. Feeley

Published: May 17, 2016
https://doi.org/10.1371/journal.pone.0155486

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Musculoskeletal injury
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Rotator cuff muscles
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Fibrosis
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Apoptosis
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Signal inhibition
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Muscle cells
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