Colorectal Cancer and the Human Gut Microbiome: Reproducibility with Whole-Genome Shotgun Sequencing

Emily Vogtmann; Xing Hua; Georg Zeller; Shinichi Sunagawa; Anita Y. Voigt; Rajna Hercog; James J. Goedert; Jianxin Shi; Peer Bork; Rashmi Sinha

doi:10.1371/journal.pone.0155362

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Open Access

Peer-reviewed

Research Article

Colorectal Cancer and the Human Gut Microbiome: Reproducibility with Whole-Genome Shotgun Sequencing

Emily Vogtmann ,

* E-mail: emily.vogtmann@nih.gov

Affiliations Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, Maryland, United States of America, Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, United States of America

http://orcid.org/0000-0003-1355-5593

⨯
Xing Hua,

Affiliation Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Georg Zeller,

Affiliation Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
⨯
Shinichi Sunagawa,

Affiliation Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
⨯
Anita Y. Voigt,

Affiliations Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany, Department of Applied Tumor Biology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany, Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Molecular Medicine Partnership Unit (MMPU), University Hospital Heidelberg and European Molecular Biology Laboratory, Heidelberg, Germany
⨯
Rajna Hercog,

Affiliation Genomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany
⨯
James J. Goedert,

Affiliation Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Jianxin Shi,

Affiliation Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Peer Bork,

Affiliations Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany, Molecular Medicine Partnership Unit (MMPU), University Hospital Heidelberg and European Molecular Biology Laboratory, Heidelberg, Germany, Max Delbrück Centre for Molecular Medicine, Berlin, Germany, Department of Bioinformatics Biocenter, University of Würzburg, Würzburg, Germany
⨯
Rashmi Sinha

Affiliation Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
⨯

Colorectal Cancer and the Human Gut Microbiome: Reproducibility with Whole-Genome Shotgun Sequencing

Emily Vogtmann,
Xing Hua,
Georg Zeller,
Shinichi Sunagawa,
Anita Y. Voigt,
Rajna Hercog,
James J. Goedert,
Jianxin Shi,
Peer Bork,
Rashmi Sinha

Published: May 12, 2016
https://doi.org/10.1371/journal.pone.0155362

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Colorectal cancer
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Shotgun sequencing
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Metagenomics
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Ribosomal RNA
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Fusobacteria
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Gene sequencing
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Microbiome
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Species diversity
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