P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes

Zeynep Seref-Ferlengez; Stephanie Maung; Mitchell B. Schaffler; David C. Spray; Sylvia O. Suadicani; Mia M. Thi

doi:10.1371/journal.pone.0155107

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Peer-reviewed

Research Article

P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes

Zeynep Seref-Ferlengez,

Affiliations Departments of Orthopaedic Surgery, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America, Laboratories of Musculoskeletal Orthopedic Research at Einstein-Montefiore (MORE), Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America

http://orcid.org/0000-0002-0873-3079

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Stephanie Maung,

Affiliations Departments of Orthopaedic Surgery, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America, Laboratories of Musculoskeletal Orthopedic Research at Einstein-Montefiore (MORE), Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America
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Mitchell B. Schaffler,

Affiliation Department of Biomedical Engineering, City College of New York, New York, NY, United States of America
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David C. Spray,

Affiliations Department of Neuroscience, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America, Laboratories of Musculoskeletal Orthopedic Research at Einstein-Montefiore (MORE), Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America
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Sylvia O. Suadicani,

Affiliations Department of Neuroscience, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America, Department of Urology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America, Laboratories of Musculoskeletal Orthopedic Research at Einstein-Montefiore (MORE), Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America
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Mia M. Thi

* E-mail: mia.thi@einstein.yu.edu

Affiliations Departments of Orthopaedic Surgery, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America, Department of Neuroscience, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America, Laboratories of Musculoskeletal Orthopedic Research at Einstein-Montefiore (MORE), Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America
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P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes

Zeynep Seref-Ferlengez,
Stephanie Maung,
Mitchell B. Schaffler,
David C. Spray,
Sylvia O. Suadicani,
Mia M. Thi

Published: May 9, 2016
https://doi.org/10.1371/journal.pone.0155107

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Glucose
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Osteocytes
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Osteoblasts
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Glucose signaling
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Diabetes mellitus
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Mannitol
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Bone density
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