Mucosal-Associated Invariant T (MAIT) Cells Are Impaired in Th17 Associated Primary and Secondary Immunodeficiencies

Yifang Gao; William Rae; Keseva Ananth Ramakrishnan; Gabriela Barcenas-Morales; Rainer Döffinger; Efrem Eren; Saul N. Faust; Christian H. Ottensmeier; Anthony P. Williams

doi:10.1371/journal.pone.0155059

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Open Access

Peer-reviewed

Research Article

Mucosal-Associated Invariant T (MAIT) Cells Are Impaired in Th17 Associated Primary and Secondary Immunodeficiencies

Yifang Gao,

Affiliation Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton and Southampton NIHR Experimental Cancer Medicine Centre, Southampton, United Kingdom
⨯
William Rae,

Affiliation Department of Clinical Immunology, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
⨯
Keseva Ananth Ramakrishnan,

Affiliation Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton and Southampton NIHR Experimental Cancer Medicine Centre, Southampton, United Kingdom
⨯
Gabriela Barcenas-Morales,

Affiliation Department of Clinical Immunology, Addenbrookes Hospital, Cambridge, United Kingdom
⨯
Rainer Döffinger,

Affiliation Department of Clinical Immunology, Addenbrookes Hospital, Cambridge, United Kingdom
⨯
Efrem Eren,

Affiliation Department of Clinical Immunology, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
⨯
Saul N. Faust,

Affiliation NIHR Wellcome Trust Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
⨯
Christian H. Ottensmeier,

Affiliation Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton and Southampton NIHR Experimental Cancer Medicine Centre, Southampton, United Kingdom
⨯
Anthony P. Williams

* E-mail: apw2@soton.ac.uk

Affiliations Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton and Southampton NIHR Experimental Cancer Medicine Centre, Southampton, United Kingdom, Department of Clinical Immunology, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
⨯

Mucosal-Associated Invariant T (MAIT) Cells Are Impaired in Th17 Associated Primary and Secondary Immunodeficiencies

Yifang Gao,
William Rae,
Keseva Ananth Ramakrishnan,
Gabriela Barcenas-Morales,
Rainer Döffinger,
Efrem Eren,
Saul N. Faust,
Christian H. Ottensmeier,
Anthony P. Williams

Published: May 11, 2016
https://doi.org/10.1371/journal.pone.0155059

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T cells
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Immune deficiency
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Thymoma
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Autoantibodies
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Respiratory infections
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Staphylococcus aureus
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