Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa

Yogesh Bhootada; Pravallika Kotla; Sergei Zolotukhin; Oleg Gorbatyuk; Zsuzsanna Bebok; Mohammad Athar; Marina Gorbatyuk

doi:10.1371/journal.pone.0154779

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Research Article

Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa

Yogesh Bhootada,

Affiliations Department of Optometry and Vision Science, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Vision Science Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Pravallika Kotla,

Affiliations Department of Optometry and Vision Science, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Vision Science Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Sergei Zolotukhin,

Affiliation Department of Pediatrics, University of Florida, Gainesville, Florida, United States of America
⨯
Oleg Gorbatyuk,

Affiliations Department of Optometry and Vision Science, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Vision Science Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Center for Neurodegeneration and Experimental Therapy, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Zsuzsanna Bebok,

Affiliations Department of Optometry and Vision Science, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Mohammad Athar,

Affiliations Department of Optometry and Vision Science, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Marina Gorbatyuk

* E-mail: mgortk@uab.edu

Affiliations Department of Optometry and Vision Science, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Vision Science Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯

Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa

Yogesh Bhootada,
Pravallika Kotla,
Sergei Zolotukhin,
Oleg Gorbatyuk,
Zsuzsanna Bebok,
Mohammad Athar,
Marina Gorbatyuk

Published: May 4, 2016
https://doi.org/10.1371/journal.pone.0154779

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Retina
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Photoreceptors
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Retinal degeneration
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Autophagic cell death
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Mouse models
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Apoptosis
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Cell death
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Stress signaling cascade
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