Generation and Improvement of Effector Function of a Novel Broadly Reactive and Protective Monoclonal Antibody against Pneumococcal Surface Protein A of Streptococcus pneumoniae

Sascha A. Kristian; Takayuki Ota; Sarah S. Bubeck; Rebecca Cho; Brian C. Groff; Tsuguo Kubota; Giuseppe Destito; John Laudenslager; Lilia Koriazova; Tomoyuki Tahara; Yutaka Kanda

doi:10.1371/journal.pone.0154616

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Open Access

Peer-reviewed

Research Article

Generation and Improvement of Effector Function of a Novel Broadly Reactive and Protective Monoclonal Antibody against Pneumococcal Surface Protein A of Streptococcus pneumoniae

Sascha A. Kristian ,

Contributed equally to this work with: Sascha A. Kristian, Takayuki Ota, Sarah S. Bubeck

Affiliation Kyowa Kirin Pharmaceutical Research, Inc., 9420 Athena Circle, La Jolla, CA 92037, United States of America
⨯
Takayuki Ota ,

Contributed equally to this work with: Sascha A. Kristian, Takayuki Ota, Sarah S. Bubeck

Affiliation Kyowa Hakko Kirin Co., Ltd., R&D Division, 1-6-1, Ōtemachi, Chiyoda-ku, Tokyo 100–8185, Japan
⨯
Sarah S. Bubeck ,

Contributed equally to this work with: Sascha A. Kristian, Takayuki Ota, Sarah S. Bubeck

* E-mail: sarah.bubeck@kyowakirin.com

Affiliation Kyowa Kirin Pharmaceutical Research, Inc., 9420 Athena Circle, La Jolla, CA 92037, United States of America
⨯
Rebecca Cho,

Affiliation Kyowa Kirin Pharmaceutical Research, Inc., 9420 Athena Circle, La Jolla, CA 92037, United States of America
⨯
Brian C. Groff,

Affiliation Kyowa Kirin Pharmaceutical Research, Inc., 9420 Athena Circle, La Jolla, CA 92037, United States of America
⨯
Tsuguo Kubota,

Affiliation Kyowa Hakko Kirin Co., Ltd., R&D Division, 1-6-1, Ōtemachi, Chiyoda-ku, Tokyo 100–8185, Japan
⨯
Giuseppe Destito,

Affiliation Kyowa Kirin Pharmaceutical Research, Inc., 9420 Athena Circle, La Jolla, CA 92037, United States of America
⨯
John Laudenslager,

Affiliation Kyowa Kirin Pharmaceutical Research, Inc., 9420 Athena Circle, La Jolla, CA 92037, United States of America
⨯
Lilia Koriazova,

Affiliation Kyowa Kirin Pharmaceutical Research, Inc., 9420 Athena Circle, La Jolla, CA 92037, United States of America
⨯
Tomoyuki Tahara,

Affiliation Kyowa Hakko Kirin Co., Ltd., R&D Division, 1-6-1, Ōtemachi, Chiyoda-ku, Tokyo 100–8185, Japan
⨯
Yutaka Kanda

Affiliation Kyowa Hakko Kirin Co., Ltd., R&D Division, 1-6-1, Ōtemachi, Chiyoda-ku, Tokyo 100–8185, Japan
⨯

Generation and Improvement of Effector Function of a Novel Broadly Reactive and Protective Monoclonal Antibody against Pneumococcal Surface Protein A of Streptococcus pneumoniae

Sascha A. Kristian,
Takayuki Ota,
Sarah S. Bubeck,
Rebecca Cho,
Brian C. Groff,
Tsuguo Kubota,
Giuseppe Destito,
John Laudenslager,
Lilia Koriazova,
Tomoyuki Tahara

Published: May 12, 2016
https://doi.org/10.1371/journal.pone.0154616

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