Segmental Isotope Labelling of an Individual Bromodomain of a Tandem Domain BRD4 Using Sortase A

Open Access

Peer-reviewed

Research Article

Felix P. Williams,

Affiliation Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Alderley Park, Macclesfield SK10 4TF, United Kingdom
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Alexander G. Milbradt,

Affiliation Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Alderley Park, Macclesfield SK10 4TF, United Kingdom
⨯
Kevin J. Embrey ,

* E-mail: Kevin.Embrey@astrazeneca.com (KJE); Romel.Bobby@astrazeneca.com (RB)

Affiliation Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Alderley Park, Macclesfield SK10 4TF, United Kingdom
⨯
Romel Bobby

* E-mail: Kevin.Embrey@astrazeneca.com (KJE); Romel.Bobby@astrazeneca.com (RB)

Affiliation Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Alderley Park, Macclesfield SK10 4TF, United Kingdom

http://orcid.org/0000-0001-5652-4098

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NMR spectroscopy
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Isotopes
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Drug interactions
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Protein domains
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Reaction time
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Glycine
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Sequence motif analysis
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Staphylococcus aureus
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