Manipulating the Prion Protein Gene Sequence and Expression Levels with CRISPR/Cas9

Open Access

Peer-reviewed

Research Article

Lech Kaczmarczyk,

Affiliation German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
⨯
Ylva Mende,

Affiliation Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany
⨯
Branko Zevnik,

Affiliation Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany
⨯
Walker S. Jackson

* E-mail: walker.jackson@dzne.de

Affiliation German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
⨯

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CRISPR
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Gene targeting
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Mouse models
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Transfection
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Cloning
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Prion diseases
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Genetic loci
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Homologous recombination
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