Mapping Breakpoints of Complex Chromosome Rearrangements Involving a Partial Trisomy 15q23.1-q26.2 Revealed by Next Generation Sequencing and Conventional Techniques

Qiong Pan; Hao Hu; Liangrong Han; Xin Jing; Hailiang Liu; Chuanchun Yang; Fengting Zhang; Yue Hu; Hongni Yue; Ying Ning

doi:10.1371/journal.pone.0154574

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Open Access

Peer-reviewed

Research Article

Mapping Breakpoints of Complex Chromosome Rearrangements Involving a Partial Trisomy 15q23.1-q26.2 Revealed by Next Generation Sequencing and Conventional Techniques

Qiong Pan ,

Contributed equally to this work with: Qiong Pan, Hao Hu

* E-mail: jonespan@gmail.com (QP); rosening@163.com (YN)

Affiliation Laboratory of Clinical Genetics, Huai’an Maternity and Child Health Care Hospital of Jiangsu Province, Yangzhou University, Huai’an, China
⨯
Hao Hu ,

Contributed equally to this work with: Qiong Pan, Hao Hu

Affiliation Department of Medical Genetics, Hunan Provincial Maternal and Child Health Hospital, Changsha, China
⨯
Liangrong Han,

Affiliation Department of Pediatrics, Huai’an Maternity and Child Health Care Hospital of Jiangsu Province, Huai’an, China
⨯
Xin Jing,

Affiliation Laboratory of Clinical Genetics, Huai’an Maternity and Child Health Care Hospital of Jiangsu Province, Yangzhou University, Huai’an, China
⨯
Hailiang Liu,

Affiliation CapitalBio Genomics Co., Ltd, Dongguan, China
⨯
Chuanchun Yang,

Affiliation BGI-Shenzhen, Shenzhen, China
⨯
Fengting Zhang,

Affiliation Laboratory of Clinical Genetics, Huai’an Maternity and Child Health Care Hospital of Jiangsu Province, Yangzhou University, Huai’an, China
⨯
Yue Hu,

Affiliation Laboratory of Clinical Genetics, Huai’an Maternity and Child Health Care Hospital of Jiangsu Province, Yangzhou University, Huai’an, China
⨯
Hongni Yue,

Affiliation Department of Pediatrics, Huai’an Maternity and Child Health Care Hospital of Jiangsu Province, Huai’an, China
⨯
Ying Ning

* E-mail: jonespan@gmail.com (QP); rosening@163.com (YN)

Affiliation Laboratory of Clinical Genetics, Huai’an Maternity and Child Health Care Hospital of Jiangsu Province, Yangzhou University, Huai’an, China
⨯

Mapping Breakpoints of Complex Chromosome Rearrangements Involving a Partial Trisomy 15q23.1-q26.2 Revealed by Next Generation Sequencing and Conventional Techniques

Qiong Pan,
Hao Hu,
Liangrong Han,
Xin Jing,
Hailiang Liu,
Chuanchun Yang,
Fengting Zhang,
Yue Hu,
Hongni Yue,
Ying Ning

Published: May 24, 2016
https://doi.org/10.1371/journal.pone.0154574

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Chromosomal translocations
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Karyotypes
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Chromosome structure and function
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Telomeres
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Giemsa staining
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Next-generation sequencing
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