mTOR Inhibition Attenuates Dextran Sulfate Sodium-Induced Colitis by Suppressing T Cell Proliferation and Balancing TH1/TH17/Treg Profile

Shurong Hu; Mengmeng Chen; Yilin Wang; Zhengting Wang; Yaofei Pei; Rong Fan; Xiqiang Liu; Lei Wang; Jie Zhou; Sichang Zheng; Tianyu Zhang; Yun Lin; Maochen Zhang; Ran Tao; Jie Zhong

doi:10.1371/journal.pone.0154564

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Open Access

Peer-reviewed

Research Article

mTOR Inhibition Attenuates Dextran Sulfate Sodium-Induced Colitis by Suppressing T Cell Proliferation and Balancing TH1/TH17/Treg Profile

Shurong Hu ,

Contributed equally to this work with: Shurong Hu, Mengmeng Chen

Affiliation Department of Gastroenterology, Ruijin hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China
⨯
Mengmeng Chen ,

Contributed equally to this work with: Shurong Hu, Mengmeng Chen

Affiliation Department of Gastroenterology, Ruijin hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China
⨯
Yilin Wang,

Affiliation Department of Surgery, Cancer hospital, Fudan University, Shanghai, PR China
⨯
Zhengting Wang,

Affiliation Department of Gastroenterology, Ruijin hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China
⨯
Yaofei Pei,

Affiliation Department of Surgery, Ruijin hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China
⨯
Rong Fan,

Affiliation Department of Gastroenterology, Ruijin hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China
⨯
Xiqiang Liu,

Affiliation Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial People’s Hospital, Hangzhou, Zhejiang Province, PR China
⨯
Lei Wang,

Affiliation Department of Gastroenterology, Ruijin hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China
⨯
Jie Zhou,

Affiliation Department of Gastroenterology, Ruijin hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China
⨯
Sichang Zheng,

Affiliation Department of Gastroenterology, Ruijin hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China
⨯
Tianyu Zhang,

Affiliation Department of Gastroenterology, Ruijin hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China
⨯
Yun Lin,

Affiliation Department of Gastroenterology, Ruijin hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China
⨯
Maochen Zhang,

Affiliation Department of Gastroenterology, Ruijin hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China
⨯
Ran Tao ,

* E-mail: jimmyzj64@hotmail.com (JZ); taohdac9@yahoo.com (RT)

Current Address: Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial Peoples’ Hospital (ZJPPH), Hangzhou, Zhejiang Province, PR China

Affiliation Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial People’s Hospital, Hangzhou, Zhejiang Province, PR China
⨯
Jie Zhong

* E-mail: jimmyzj64@hotmail.com (JZ); taohdac9@yahoo.com (RT)

Current address: Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, PR China

Affiliation Department of Gastroenterology, Ruijin hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China
⨯

mTOR Inhibition Attenuates Dextran Sulfate Sodium-Induced Colitis by Suppressing T Cell Proliferation and Balancing TH1/TH17/Treg Profile

Shurong Hu,
Mengmeng Chen,
Yilin Wang,
Zhengting Wang,
Yaofei Pei,
Rong Fan,
Xiqiang Liu,
Lei Wang,
Jie Zhou,
Sichang Zheng

Published: April 29, 2016
https://doi.org/10.1371/journal.pone.0154564

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15 May 2016
08:21 GMT
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Correction of the name of the co-first author "Mengmeng Cheng" Posted by jzhong850 on 15 May 2016 at 08:21 GMT

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