Melatonin Preserves Blood-Brain Barrier Integrity and Permeability via Matrix Metalloproteinase-9 Inhibition

Himakarnika Alluri; Rickesha L. Wilson; Chinchusha Anasooya Shaji; Katie Wiggins-Dohlvik; Savan Patel; Yang Liu; Xu Peng; Madhava R. Beeram; Matthew L. Davis; Jason H. Huang; Binu Tharakan

doi:10.1371/journal.pone.0154427

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Open Access

Peer-reviewed

Research Article

Melatonin Preserves Blood-Brain Barrier Integrity and Permeability via Matrix Metalloproteinase-9 Inhibition

Himakarnika Alluri,

Affiliation Department of Surgery, Baylor Scott & White Health/Texas A&M University Health Science Center College of Medicine, Temple, Texas, United States of America
⨯
Rickesha L. Wilson,

Current address: Department of Surgery, University of Connecticut School of Medicine, Farmington, CT, United States of America

Affiliation Department of Surgery, Baylor Scott & White Health/Texas A&M University Health Science Center College of Medicine, Temple, Texas, United States of America
⨯
Chinchusha Anasooya Shaji,

Affiliation Department of Surgery, Baylor Scott & White Health/Texas A&M University Health Science Center College of Medicine, Temple, Texas, United States of America
⨯
Katie Wiggins-Dohlvik,

Affiliation Department of Surgery, Baylor Scott & White Health/Texas A&M University Health Science Center College of Medicine, Temple, Texas, United States of America
⨯
Savan Patel,

Affiliation Department of Surgery, Baylor Scott & White Health/Texas A&M University Health Science Center College of Medicine, Temple, Texas, United States of America
⨯
Yang Liu,

Affiliation Department of Medical Physiology, Texas A&M University Health Science Center College of Medicine, Temple, Texas, United States of America
⨯
Xu Peng,

Affiliation Department of Medical Physiology, Texas A&M University Health Science Center College of Medicine, Temple, Texas, United States of America
⨯
Madhava R. Beeram,

Affiliation Department of Pediatrics, Baylor Scott & White Health/Texas A&M University Health Science Center College of Medicine, Temple, Texas, United States of America
⨯
Matthew L. Davis,

Affiliation Department of Medical Physiology, Texas A&M University Health Science Center College of Medicine, Temple, Texas, United States of America
⨯
Jason H. Huang,

Affiliation Department of Neurosurgery, Baylor Scott & White Health/ Texas A&M University Health Science Center College of Medicine, Temple, Texas, United States of America
⨯
Binu Tharakan

* E-mail: btharakan@medicine.tamhsc.edu

Affiliation Department of Surgery, Baylor Scott & White Health/Texas A&M University Health Science Center College of Medicine, Temple, Texas, United States of America
⨯

Melatonin Preserves Blood-Brain Barrier Integrity and Permeability via Matrix Metalloproteinase-9 Inhibition

Himakarnika Alluri,
Rickesha L. Wilson,
Chinchusha Anasooya Shaji,
Katie Wiggins-Dohlvik,
Savan Patel,
Yang Liu,
Xu Peng,
Madhava R. Beeram,
Matthew L. Davis,
Jason H. Huang

Published: May 6, 2016
https://doi.org/10.1371/journal.pone.0154427

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Melatonin
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Traumatic brain injury
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Blood-brain barrier
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Tight junctions
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Endothelial cells
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Small interfering RNA
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